Review Article
A Clinical Review of the Association of Thyroid Stimulating Hormone and Cognitive Impairment
Table 2
Cross-sectional studies. Relationship between subclinical hyperthyroidism (SH) and cognitive decline.
| | Author | Study size () | Mean age | Participants
thyroid status | Thyroid function
(normal range) | Outcomes |
| |
Bensenor et al., [31]
2010
| 1119 |
ND = 71.9 | SH and euthyroid | TSH (0.4–4.0 mU/L)
FT4 (0.77–2.19 ng/L) | Positive association SH and dementia especially vascular dementia |
| Ceresini et al., [32]
2009 | 916 | >65 | SH and euthyroid | TSH (0.46–4.68 mU/L)
FT4 (0.77–2.19 ng/L) | SH group had significantly lower MMSE compared to the euthyroid group |
| | Zhang et al., [33] 2012 | 40 | 67.08 | All thyroid status | TSH (0.3–5.0 mU/L)
TT4 (58.1–140.6 nmol/L)
TT3 (0.92–2.97 nmol/L) | Lower TSH in euthyroid AD patients with agitation and irritability symptoms |
| | de Jongh et al., [34] 2011 | 1219
(34 SH) | 75.5 | Euthyroid, SH, and subclinical hypothyroidism | TSH (0.3–4.5 mU/L)
FT4, FT3 | No association SH and impaired global cognitive function |
| Quinlan et al., [35]
2010 | 69 | 60.9–66.8 | All thyroid status | TSH, FT4, TT4,
TT3 (1.4–1.6 nmol/L) | Higher TT3 was associated with more cognitive impairment in MCI group |
|
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