Research Article
The Effect of Pioglitazone on Antioxidant Levels and Renal Histopathology in Streptozotocin-Induced Diabetic Rats
Table 3
Renal tissue levels of superoxide dismutase, catalase, reduced glutathione, malondialdehyde, nitric oxide, tumor necrosis factor-alpha, and interleukin-6.
| | | SOD
U/mg
protein | CAT
k/s/mg
protein | GSH
mg/g
protein | MDA
nmol/mg
protein | NO
pg/mg
protein | TNF-α
pg/mg
protein | IL-6
ng/g
protein |
| Control group
() | 6.1 ± 2.7 | 1.8 ± 0.6 | 61.5 ± 41.8 | 1.3 ± 0.5 | 51.3 ± 45.5 | 191.8 ± 73.11 | 348.7 ± 137.9 | Diabetic control group
() | 5.1 ± 4.81 | 1.5 ± 0.6 | 56.6 ± 31.0 | 2.8 ± 1.5* | 16.6 ± 11.8 | 183.7 ± 36.8 | 323.3 ± 93.3 | 10 mg pioglitazone group
() | 6.9 ± 3.1 | 1.7 ± 0.7 | 92.3 ± 32.7 | 2.1 ± 1.1 | 15.1 ± 8.8 | 207.8 ± 86.6 | 329.7 ± 146.7 | 30 mg pioglitazone group
() | 5.7 ± 2.9 | 2.6 ± 2.2 | 74.5 ± 47.8 | 1.7 ± 0.6 | 22.8 ± 20.8 | 198.1 ± 68.3 | 358.2 ± 46.2 |
|
|
SOD: superoxide dismutase; CAT: catalase; GSHr: reduced glutathione; MDA: malondialdehyde; NO: nitric oxide; TNF-α: tumor necrosis factor-alpha; IL-6: Interleukin-6. .
|
