Evaluation of Packed-Bed Reactor and Continuous Stirred Tank Reactor for the Production of Colchicine Derivatives

Table 3

ANOVA for response surface quadratic model to verify whether developed model is significant or nonsignificant.

Source	Sum of squares	Degrees of freedom	Mean square	F value	P value (prob > F)
Model	66.63	6	11.1	176.23	<0.0001*
A-DO	45.96	1	45.96	729.41	<0.0001
B-Colchicine	13.71	1	13.71	217.54	<0.0001
C-Process time	3.37	1	3.37	53.51	<0.0001
AB	2.82	1	2.82	44.76	<0.0001
AC	0.56	1	0.56	8.83	0.0108
BC	0.21	1	0.21	3.3	0.0923
Residual	0.82	13	0.063
Lack of fit**	0.82	8	0.1

∗significant, **nonsignificant.