Table of Contents
ISRN Neurology
Volume 2013, Article ID 867575, 6 pages
Clinical Study

Quantifying Gait Impairment Using an Instrumented Treadmill in People with Multiple Sclerosis

1Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
2Institute of Motor Functions, Sheba Medical Center, Tel Hashomer, Israel
3Sackler Faculty of Medicine, Tel-Aviv University, Israel

Received 26 May 2013; Accepted 13 June 2013

Academic Editors: D. E. Bulman, A. Mamelak, A. K. Petridis, and D. Schiffer

Copyright © 2013 Alon Kalron et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Objective. Treadmill gait analysis has been proposed as an attractive alternative for overground walking measuring systems. The purpose of this study was twofold: first to determine spatiotemporal parameters of treadmill gait in patients with multiple sclerosis (MS) and second to examine whether these parameters are associated with specific functional impairments in this cohort. Method. Eighty-seven relapsing-remitting patients diagnosed with MS, 50 women and 37 men, aged 40.9 ± 11.9 with an expanded disability status scale (EDSS) score of 2.7 ± 1.6, participated in this study. Twenty-five apparently healthy subjects, 14 women and 11 men, aged 38.5 ± 9.4, served as controls. Spatiotemporal gait parameters were obtained using the Zebris FDM-T Treadmill (Zebris Medical GmbH, Germany). People with MS demonstrated significantly shorter steps, extended stride time, wider base of support, longer step time, reduced single support phase, and a prolonged double support phase compared to the healthy controls. The EDSS score was significantly correlated with all spatiotemporal gait parameters. Conclusion. The instrumented treadmill may be an effective tool in assessing ambulation capabilities of people with MS.