Review Article

Diagnostically Relevant Molecular Markers in Head and Neck Neoplasms

Table 1

Proposed classification of diagnostic markers.

Markers for tumors with muscle differentiation Muscle specific actin
Desmin
Myogenin
Myoglobin
MyoD1

Markers for tumors with neural differentiationS100
CD57
P75NTR
Neurofilament
GFAP
Neuron specific enolase
Leu-7
Myelin basic protein

Markers for tumors with Vascular cell differentiation Von Willibrand-Factor
CD-34
CD-31
Type 1V collagen
Ulex europaeus

Markers for histiocytesCD-68

Marker for mesenchymal tumors Vimentin

Marker for epithelial tumorsCytokeratin
Integrin
Filaggrin
Involucrin
Desmosomal proteins

Markers for melaninS1OO
HMB-45
Melanin A
Microphthalmia factor

Markers for chondrocytes Leu-6
Leu-7
Leu-8
S100

Markers for bone Alkaline Phosphatase
Type 1 collagen
Type 5 collagen
BMP-2
BMP-7
TG F β
PDGF
IGF
Bone sialoprotein
Osteopontin
Osteocalcin
Osterix
Receptor activated nuclear factor