The Human Frontal Lobes and Frontal Network Systems: An Evolutionary, Clinical, and Treatment Perspective
Table 15
PET brain patterns in dementias.
Dementia subtype
18 FFDG PET hypometabolism pattern
Alzheimer
Relatively symmetric parietotemporal, medial temporal, posterior cingulate, and frontal association cortex to lesser degree
AD variant (PCAS)
Occipital hypometabolism predominates
FTD behavioral variant
Frontal and anterior temporal hypometabolism
PDD
Temporoparietal, may be similar to AD
DLBD
Occipital and temporal hypometabolism
CVD
Cortical and subcortical, singular or multifocal, correlating with structural imaging abnormality
CBD
Global reduction in metabolism as well as asymmetric prefrontal, premotor, sensorimotor superior temporal, parietal hypometabolism with thalamic hypometabolism contralateral to limb apraxia
Huntington’s
Caudate nucleus hypometabolism and frontal association cortex to a lesser degree
PSP
Caudate nucleus, putamen, thalamus, pons, and superior and anterior frontal cortex
PCAS: posterior cortical atrophy syndrome. PSP: progressive supranuclear palsy. FDG PET increases diagnostic accuracy beyond that derived from clinical evaluation. Adapted and modified from [35].