Table of Contents
ISRN Emergency Medicine
Volume 2013 (2013), Article ID 896802, 6 pages
http://dx.doi.org/10.1155/2013/896802
Review Article

The Mortality in Emergency Department Sepsis Score as a Predictor of 1-Month Mortality among Adult Patients with Sepsis: Weighing the Evidence

1Faculty of Medicine, University Indonesia, Salemba Raya 6, Jakarta 10430, Indonesia
2Accident and Emergency Department, Changi General Hospital, Singapore 2 Simei Street 3, Singapore 529889

Received 16 June 2013; Accepted 15 July 2013

Academic Editors: C. D. Boucek, F. Folke, and G. Volpicelli

Copyright © 2013 Bayushi Eka Putra and Ling Tiah. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the performance of Mortality in Emergency Department Sepsis (MEDS) score in comparison to biomarkers as a predictor of mortality in adult emergency department (ED) patients with sepsis. Methods. A literature search was performed using PubMed, ScienceDirect, SpringerLink, and Ovid databases. Studies were appraised by using the C2010 Consensus Process for Levels of Evidence for prognostic studies. The respective values for area under the curve (AUC) were obtained from the selected articles. Results. Four relevant articles met the selection process. Three studies defined the 1-month mortality as death occurring within 28 days of ED presentation, while the remaining one subcategorised the outcome measure as (5-day) early and (6- to 30-day) late mortality. In all four studies, the MEDS score performed better than the respective comparators (C-reactive protein, lactate, procalcitonin, and interleukin-6) in predicting mortality with an AUC ranging from 0.78 to 0.89 across the studies. Conclusion. The MEDS score has a better prognostic value than the respective comparators in predicting 1-month mortality in adult ED patients with suspected sepsis.