Figure 1: Schematic representation of B19V genome organization and functional mapping. Top: open reading frames identified in the positive strand of genome; arrows indicate the coding regions for viral proteins positioned on the ORF map. Center: genome organization, with distinct representation of the terminal and internal regions and indication of the positions of promoter (P6), splice donor (D1, D2), splice acceptor (A1-1/2, A2-2/2), and cleavage-polyadenylation (pAp1, pAp2, and pAd) sites. Bottom: viral mRNAs species; black boxes indicate the exon composition and light boxes indicate the ORFs contained within mRNAs.