No Association between Depression and Risk of Hepatocellular Carcinoma in Older People in Taiwan

Table 1

Characteristics between hepatocellular carcinoma group and comparison group.

	Hepatocellular carcinoma				P value
	No		Yes
	𝑁 = 7260		𝑁 = 1815
	𝑛	(%)	𝑛	(%)
Age group (year)
65–74	4260	58.68	1065	58.68	0.99
75–84	3000	41.32	750	41.32
Sex
Men	4528	62.37	1132	62.37	0.99
Women	2732	37.63	683	37.63
Comorbidities before index date*
Depression	385	5.30	114	6.28	0.10
Diabetes mellitus	1941	26.74	636	35.04	<0.0001
Cirrhosis	137	1.89	990	54.56	<0.0001
Other chronic hepatitis	1163	16.02	1033	56.91	<0.0001
Hepatitis B infection	112	1.54	361	19.89	<0.0001
Hepatitis C infection	135	1.86	600	33.06	<0.0001
Alcoholism	57	0.79	24	1.32	0.03

Data are presented as the number of subjects in each group, with percentages given in parentheses.
Chi-square test comparing subjects with and without hepatocellular carcinoma.
*Comorbidities included before index date were as follows: depression (ICD-9 codes 296.2-296.3, 300.4, and 311), diabetes mellitus (ICD-9 codes 250), cirrhosis (ICD-9 codes 571.2, and 571.5-571.6), other chronic hepatitis (ICD-9 codes 571.40-571.41, 571.49, and 571.8-571.9), hepatitis B infection (ICD-9 codes V02.61, 070.20, 070.22, 070.30, and 070.32), hepatitis C infection (ICD-9 codes V02.62, 070.41, 070.44, 070.51, and 070.54), and alcoholism (ICD-9 codes 303, 305.00, 305.01, 305.02, 305.03, and V11.3).