Table of Contents
ISRN Genetics
Volume 2013 (2013), Article ID 905156, 6 pages
http://dx.doi.org/10.5402/2013/905156
Research Article

Reference Analysis in a Misclassification Model for the Meiosis I Nondisjunction Fraction in Trisomies

Department of Statistics, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil

Received 22 October 2012; Accepted 9 November 2012

Academic Editors: A. Esquela Kerscher, R. W. Pereira, and T. Saito

Copyright © 2013 Rosangela H. Loschi and Vinicius D. Mayrink. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The determination of the meiosis I nondisjunction fraction plays an important role in identifying the characteristics of affected individuals and their mothers, which can generate aneuploidies. The number of individuals with one, two, and three peaks pattern is used to obtain the information; however, the data are susceptible to misclassification. We review the misclassification model previously introduced in the literature which considers a common misclassification error. This paper aims to introduce a joint prior distribution for the meiosis I nondisjunction fraction and the misclassification error. We prove that the reference prior is a proper distribution. We analyze a Brazilian Down syndrome dataset and compare the results with those obtained through Bayes-Laplace and beta prior distributions.