Effect of Physical Exercise on the Level of DNA Damage in Chronic Obstructive Pulmonary Disease Patients

Table 2

Pulmonary function and comet assay results in the COPD, PE-COPD patients, and control group.

Characteristics	COPD (𝑛=36)	PE-COPD (𝑛=15)	Control (𝑛=51)	^∗𝑃 value
FEV1 (% predicted)	41.78±18.60^#	45.60±20.42^#	86.14±11.72	NS
FVC (% predicted)	60.28±19.34^#	66.80±15.04^#	90.75±13.67	NS
FEV1/FVC (% predicted)	69.11±20.23^#	65.07±18.17^#	105.24±70.28	NS
Damage index—alkaline comet assay	32.28±24.96	47.33±24.03^#	26.65±27.96	NS
Damage index—1 h of MMS treatment	131.67±64.54	81.80±23.19^∗	103.12±60.38	0.019
Damage index—3 h of MMS treatment	190.47±105.17^#	83.13±43.58^∗	60.61±61.45	0.000
Damage index—neutral comet assay	38.47±32.59	68.27±19.70^∗	37.49±38.05	0.001
Damage index—FPG comet assay	37.78±26.05	71.60±23.61^∗#	39.78±23.60	0.001
Damage index—ENDO III comet assay	38.94±26.70	70.67±16.72^∗#	40.15±34.04	0.002

Data are presented as mean ± SD; FEV₁: forced expiratory volume in one second; FVC: forced vital capacity; ^∗𝑃<0.05, COPD compared with the PE-COPD; ^#𝑃<0.05, COPD or PE-COPD compared with the control group.