Marked Effects of Tachykinin in Myositis Both in the Experimental Side and Contralaterally: Studies on NK-1 Receptor Expressions in an Animal Model

Figure 9

(a)–(d) NK-1R immunoreactions in the walls of blood vessels located in myositis areas or close to these areas are shown (preabsorption control in (d)). Sections are from gastrocnemius muscles from the exercised side, the 6-week (a) and 1-week (b) groups, and from the nonexercised side, 3-week group (c, d). Note that there are NK-1R immunoreactions in the blood vessel walls in both exercised and nonexercised sides (arrows, (a)–(c)). The reactions are observed in the endothelial layer of the vessels. There is no reaction in the preabsorption control (d). The vessel shown in (d) conforms to that in (c) but was sectioned in another level of the sectioning, why the vessel morphology is different. Asterisks in the lumen of the blood vessel (c, d). Bars = 25 μm. (e) Immunostaining for NK-1R. Soleus muscle specimen of the 6-week group, nonexercised side. There are immunoreactions in fibroblast-like cells (arrows). Bar = 25 μm.