Suppression of Receptor for Advanced Glycation End Products Improves Angiogenic Responses to Ischemia in Diabetic Mouse Hindlimb Ischemia Model
Figure 4
The protein expression levels of VEGF, RAGE, and HMGB-1 in hindlimb muscle tissues. (a) Representative Western blot of VEGF protein level in the ischemic gastrocnemius muscle tissues of control, diabetic mice and sRAGE-treated diabetic mice on postoperative day 14. (b) VEGF protein level in the ischemic gastrocnemius muscle tissues by ELISA. (c) Representative Western blot of RAGE protein level in the ischemic gastrocnemius muscle tissues of control, diabetic mice and sRAGE-treated diabetic mice on postoperative day 14. (d) RAGE protein level in the ischemic gastrocnemius muscle tissues by ELISA. (e) Representative Western blot of HMGB-1 protein level in the ischemic gastrocnemius muscle tissues of control, diabetic mice and sRAGE-treated diabetic mice on postoperative day 14. (f) HMGB-1 protein level in the ischemic gastrocnemius muscle tissues by ELISA.
