Table of Contents
ISRN Obesity
Volume 2013, Article ID 910586, 5 pages
http://dx.doi.org/10.1155/2013/910586
Clinical Study

Surgical Stress Induces an Amplified Inflammatory Response in Patients with Type 2 Diabetes

1Emory Endosurgery Unit Division of General and Gastrointestinal Surgery, Department of Surgery, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30322, USA
2Department of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907-2059, USA

Received 5 December 2012; Accepted 30 December 2012

Academic Editors: S. J. Pintauro and J. Saleh

Copyright © 2013 Edward Lin and Nana Gletsu-Miller. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Lin, S. E. Calvano, and S. F. Lowry, “Cytokine response in abdominal surgery,” in Cytokines and the Abdominal Surgeon, M. Schein and L. Wise, Eds., pp. 17–34, R.G. Landes, Austin, Tex, USA, 1998. View at Google Scholar
  2. E. Lin and S. F. Lowry, “Inflammatory cytokines in major surgery: a functional perspective,” Intensive Care Medicine, vol. 25, no. 3, pp. 255–257, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. E. J. B. Ramos, Y. Xu, I. Romanova et al., “Is obesity an inflammatory disease?” Surgery, vol. 134, no. 2, pp. 329–335, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Esposito, A. Pontillo, C. Di Palo et al., “Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial,” Journal of the American Medical Association, vol. 289, no. 14, pp. 1799–1804, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Gonzalez, S. P. Bowers, K. R. Venkatesh, E. Lin, and C. D. Smith, “Preoperative factors predictive of complicated postoperative management after Roux-en-Y gastric bypass for morbid obesity,” Surgical Endoscopy, vol. 17, no. 12, pp. 1900–1904, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Gracie, S. E. Robertson, and I. B. McInnes, “Interleukin-18,” Journal of Leukocyte Biology, vol. 73, no. 2, pp. 213–224, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Gerdes, G. K. Sukhova, P. Libby, R. S. Reynolds, J. L. Young, and U. Schönbeck, “Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis,” Journal of Experimental Medicine, vol. 195, no. 2, pp. 245–257, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. J. A. Jordan, R. F. Guo, E. C. Yun et al., “Role of IL-18 in acute lung inflammation,” Journal of Immunology, vol. 167, no. 12, pp. 7060–7068, 2001. View at Google Scholar · View at Scopus
  9. S. Blankenberg, L. Tiret, C. Bickel et al., “Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina,” Circulation, vol. 106, no. 1, pp. 24–30, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Zaremba and J. Losy, “Interleukin-18 in acute ischaemic stroke patients,” Neurological Sciences, vol. 24, no. 3, pp. 117–124, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Moriwaki, T. Yamamoto, Y. Shibutani et al., “Elevated levels of interleukin-18 and tumor necrosis factor-α in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy,” Metabolism, vol. 52, no. 5, pp. 605–608, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. S. R. Grobmyer, E. Lin, S. F. Lowry et al., “Elevation of IL-18 in human sepsis,” Journal of Clinical Immunology, vol. 20, no. 3, pp. 212–215, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Weighardt, C. D. Heidecke, K. Emmanuilidis et al., “Sepsis after major visceral surgery is associated with sustained and interferon-γ-resistant defects of monocyte cytokine production,” Surgery, vol. 127, no. 3, pp. 309–315, 2000. View at Google Scholar · View at Scopus
  14. A. Oberholzer, U. Steckholzer, M. Kurimoto, O. Trentz, and W. Ertel, “Interleukin-18 plasma levels are increased in patients with sepsis compared to severely injured patients,” Shock, vol. 16, no. 6, pp. 411–414, 2001. View at Google Scholar · View at Scopus
  15. A. Sablotzki, I. Friedrich, J. Mühling et al., “The systemic inflammatory response syndrome following cardiac surgery: different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunction,” Perfusion, vol. 17, no. 2, pp. 103–109, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. R. J. Feezor, C. Oberholzer, H. V. Baker et al., “Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria,” Infection and Immunity, vol. 71, no. 10, pp. 5803–5813, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Maerten, C. Shen, S. Colpaert et al., “Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models,” Clinical and Experimental Immunology, vol. 135, no. 2, pp. 310–317, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Esposito, A. Pontillo, M. Ciotola et al., “Weight loss reduces interleukin-18 levels in obese women,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 8, pp. 3864–3866, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Gletsu, E. Lin, J. L. Zhu et al., “Increased plasma interleukin 6 concentrations and exaggerated adipose tissue interleukin 6 content in severely obese patients after operative trauma,” Surgery, vol. 140, no. 1, pp. 50–57, 2006. View at Publisher · View at Google Scholar
  20. J. Spranger, A. Kroke, M. Möhlig et al., “Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study,” Diabetes, vol. 52, no. 3, pp. 812–817, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Tsigos, D. A. Papanicolaou, I. Kyrou, R. Defensor, C. S. Mitsiadis, and G. P. Chrousos, “Dose-dependent effects of recombinant human interleukin-6 on glucose regulation,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 12, pp. 4167–4170, 1997. View at Google Scholar · View at Scopus
  22. R. F. Grimble, “Inflammatory status and insulin resistance,” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 5, no. 5, pp. 551–559, 2002. View at Google Scholar
  23. J. Hirosumi, G. Tuncman, L. Chang et al., “A central, role for JNK in obesity and insulin resistance,” Nature, vol. 420, no. 6913, pp. 333–336, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Emanuelli, P. Peraldi, C. Filloux et al., “SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-α in the adipose tissue of obese mice,” Journal of Biological Chemistry, vol. 276, no. 51, pp. 47944–47949, 2001. View at Google Scholar · View at Scopus
  25. E. Van Exel, J. Gussekloo, A. J. M. De Craen, M. Frölich, A. B. V. D. Wiel, and R. G. J. Westendorp, “Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: the Leiden 85-plus study,” Diabetes, vol. 51, no. 4, pp. 1088–1092, 2002. View at Google Scholar · View at Scopus
  26. E. Lin, S. E. Calvano, and S. F. Lowry, “Inflammatory cytokines and cell response in surgery,” Surgery, vol. 127, no. 2, pp. 117–126, 2000. View at Google Scholar · View at Scopus
  27. M. Laimer, C. F. Ebenbichler, S. Kaser et al., “Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention,” International Journal of Obesity, vol. 26, no. 5, pp. 659–662, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. V. Vicennati, A. Vottero, C. Friedman, and D. A. Papanicolaou, “Hormonal regulation of interleukin-6 production in human adipocytes,” International Journal of Obesity, vol. 26, no. 7, pp. 905–911, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Xu, G. T. Barnes, Q. Yang et al., “Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1821–1830, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. S. P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A. W. Ferrante, “Obesity is associated with macrophage accumulation in adipose tissue,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1796–1808, 2003. View at Publisher · View at Google Scholar · View at Scopus