Table 1: Comparison of the performance characteristics of the proposed method with some of the existing chromatographic/spectrophotometric methods.

Sl No.Reagent/s usedMethodologyLinear rangeRemarksReferences

1NaClO4—buffer ethanolDerivative spectrophotometry0.62–10.14  g/mL Sensitive but lack of selectivity[19]

2Methyl orangeFormation of ion pair with methyl orange and the absorbance was measured at 425 nm0.79–25.3  g/mLLess sensitive[21]

3Eriochrome cyanine RReacts in neutral medium with imipramine forming reddish compound10–80  g/mLLess sensitive and has narrow range[22]

p-chloranilic acid
First derivative of ratio spectra
Formation of purple colored charge transfer complex
5–30  g/mL
20–200  g/mL
Less sensitive and very narrow range[20]

5Azocarmine G
Naphthalene blue
Woolfast blue BL
Extracts of the ion associates
exhibit absorption maxima
at 550 (ACG),
620 (NB), and
590 (WFB BL) nm
2.0–12.0  g/mL
4.0–16.0  g/mL
1.0–12.0  g/mL
Sensitive but requires tedious extraction procedures[23]

63-Methylbenzothiazolin-2-one hydrazone-iron(III)chlorideOxidative coupling of the drugs with 3-methylbenzothiazolin-2-one hydrazone which shows maximum absorption at 630 nm1.0–25  g/mL
( = 3.20 × 103)
Less sensitive[24]

7Mobile phase consisting of a mixture of acetonitrile and ammonium acetate buffer of pH-5 (30 : 30 : 40, v/v/v)UPLC0.2–3  g/mLHighly sensitive and selectiveDeveloped  method