Table of Contents
ISRN Emergency Medicine
Volume 2013, Article ID 914840, 6 pages
Clinical Study

Clinical Findings in Albanian Patients with 2009 Influenza AH1N1 Admitted at the Intensive Care Unit

1“Mother Theresa” School of Medicine, Service of Infectious Diseases, Dibra Street, No. 372, Tirana, Albania
2Institute of Public Health, Control of Infectious Diseases Department, Tirana, Albania
3“Mother Theresa” School of Medicine, Service of Toxicology, Reanimation, Anesthesiology and Emergency Medicine, Tirana, Albania
4University of Tirana, Faculty of Technical Medical Sciences, Department of Clinical Subjects, Tirana, Albania
5Stanford University School of Medicine, Stanford, CA 94305, USA
6“Mother Theresa” School of Medicine, Department of Allergology and Clinical Immunology, Tirana, Albania
7University of Tirana, Faculty of Technical Medical Sciences, Department of Preclinical Subjects, Tirana, Albania

Received 13 March 2013; Accepted 16 April 2013

Academic Editors: C.-C. Chang and O. Karcioglu

Copyright © 2013 Arben Ndreu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Due to the ease of cross-continent spread of infectious diseases, the 2009 influenza AH1N1 (H1N1) affected many countries. This observational prospective study looked at Albanian patients admitted with 2009 H1N1 at the ICU of the Department of Infectious Diseases at the University Hospital Center of Tirana, from November 2009 to March 2010. Demographic data, symptoms, comorbidities, and clinical outcomes were collected from each patient. The number of days spent in the ICU was recorded for each patient along with their radiological and laboratory findings, and outcome at discharge. Critical illness occurred in 31 patients admitted with confirmed 2009 H1N1. The median age of patients was 35 years. Five (16.1%) patients required endotracheal intubation; noninvasive oxygen therapy (NIV) was used in 15 (48.4%) patients via nasal tube; and continuous positive airway pressure (CPAP) and pressure support ventilation (PSV) oxygen masks were used in 11 (35.5%) patients. All patients were treated with oseltamivir. Four patients admitted and treated did not survive. Critical illness in the setting of 2009 H1N1 admitted in the ICU predominantly affected young adults. NIV could play a role in treating 2009 influenza H1N1 infection-related hypoxemic respiratory failure that was associated with severe hypoxemia, pneumonia, requirement for prolonged mechanical ventilation, and the frequent use of antiviral therapy.