Critical Analysis of Strand-Biased Somatic Mutation Signatures in TP53 versus Ig Genes, in Genome-Wide Data and the Etiology of Cancer
Table 9
Somatic point mutation patterns in the TP53 mutated breast cancers in Nik-Zainal et al. exomic data [22].
(a) PD3890a Brac1
Original base
Mutant base
A
T
C
G
Total
Statistics
A
—
4
5
3
12
AT
NS
T
3
—
5
7
15
A>G versus T>C
NS
C
10
19
—
10
39
GC
NS
G
13
7
18
—
38
G>A versus C>T
NS
G>T versus C>A
NS
G>C versus C>G
NS
(b) PD4005a Brac1
Original base
Mutant base
A
T
C
G
Total
Statistics
A
—
2
6
5
13
AT
NS
T
6
—
8
5
19
A>G versus T>C
NS
C
7
24
—
17
48
GC
NS
G
22
10
13
—
45
G>A versus C>T
NS
G>T versus C>A
NS
G>C versus C>G
NS
(c) PD4109a triple negative
Original base
Mutant base
A
T
C
G
Total
Statistics
A
—
11
5
11
27
AT
1.35x
NS
T
7
—
7
6
20
A>G versus T>C
1.57x
NS
C
8
25
—
20
53
GC
1.4x
NS
G
33
18
23
—
74
G>A versus C>T
1.32x
NS
G>T versus C>A
2.25x
NS
G>C versus C>G
1.15x
NS
(d) PD4199a ER−ve, HER2+ve
Original base
Mutant base
A
T
C
G
Total
Statistics
A
—
1
2
4
7
AT
NS
T
1
—
3
1
5
A>G versus T>C
NS
C
6
23
—
19
48
GC
2.0x
G
56
8
32
—
96
G>A versus C>T
2.43x
G>T versus C>A
1.33x
NS
G>C versus C>G
1.68x
NS
From exome Supplementary data from Nik-Zainal et al. 2012 [22]. The numbers in the table are the number of mutations scored. : total number of exomic mutations.
