Table of Contents
ISRN Endocrinology
Volume 2013, Article ID 934797, 5 pages
http://dx.doi.org/10.1155/2013/934797
Research Article

Effect of Polyherbal Mixtures on the Treatment of Diabetes

1Hi-Tech Research and Development Centre, Konark Institute of Science and Technology, Bhubaneswar, Odisha 752050, India
2P.G. Department of Botany, Utkal University, Bhubaneswar, Odisha 751004, India
3Department of Biotechnology, Rama Devi Women’s (Auto) College, Bhubaneswar, Odisha 751022, India
4Centre for Biotechnology, SOA University, Bhubaneswar, Odisha 751003, India

Received 27 February 2013; Accepted 20 March 2013

Academic Editors: O. Giampietro and A. O. Wong

Copyright © 2013 Aparajeya Panda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400 mg/kg b.w. produced a significant decrease in blood glucose level by 69.6%, 70.97%, 64.45%, 71.82%, and 64.44% after 21 days of treatment. The elevated level of SGPT, SGOT, and ALP in the diabetic controlled group reflected the significant alteration of liver function by STZ induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal by these mixtures for all the estimated parameters. The results of the mixtures on treated group were found to restore the glycemic level to the near normal level thereby indicating antihyperglycemic activity of the formulated mixtures.