Research Article
Sensitive Spectrophotometric Determinations of Paracetamol and Protriptyline HCl Using 3-Chloro-7-hydroxy-4-methyl-2H-chromen-2-one
Table 1
Spectral and statistical data for the determination of drugs.
| Parameters | Drugs | PCT | PTP |
| (nm) | 545 | 468 | Beer’s law limits (µg/mL) | 10.00–60.00 | 40.00–160.00 | Molar absorptivity (L mol−1 cm−1) | 0.12 × 104 | 0.55 × 104 | Sandell’s sensitivity (µg cm−2) | 0.11 × 10−2 | 0.54 × 10−2 | Limit of detection* (µg mL−1) | 0.0578 | 0.1527 | Limit of quantification* (µg mL−1) | 0.1753 | 0.5840 | Regression equation** | | | Slope () | 0.0065 | 0.0017 | Intercept () | 0.0280 | 0.0025 | Correlation coefficient () | 0.9963 | 0.9994 |
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Limit of detection calculated according to ICH guidelines. is the absorbance and concentration in µg mL−1.
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