Differential Prognostic Indicators for Locoregional Recurrence, Distant Recurrence, and Death of Breast Cancer

Table 3

Effect (hazard ratio, HR) of clinical profiles and treatment on locoregional recurrence, distance recurrence, and death in breast cancer (𝑛=829), multivariable analysis (reduced model).

Prognostic factors	Locoregional recurrence		Distant recurrence		Death
	HR (95% CI)	𝑃 value	HR (95% CI)	𝑃 value	HR (95% CI)	𝑃 value
Age (year)
>45 versus ≤45	1.07 (0.64–1.78)	0.801	0.75 (0.50–1.13)	0.164	0.93 (0.62–1.40)	0.722
Pathological tumor size (cm)
>2 versus ≤2	1.46 (0.87–2.45)	0.148	1.26 (0.80–1.97)	0.316	1.56 (1.02–2.40)	0.040
Stage
3 versus 1 and 2	1.65 (0.94–2.91)	0.081	2.44 (1.57–3.80)	<0.001	2.17 (1.42–3.32)	<0.001
Positive axillary lymph nodes
>3 versus ≤3	2.43 (1.35–4.37)	0.003	1.79 (1.10–2.93)	0.020	2.16 (1.36–3.43)	0.001
LVI
Present versus absent	2.01 (1.09–3.71)	0.026	1.64 (0.96–2.83)	0.073	2.87 (1.69–4.87)	<0.001
Treatment
Radiotherapy
Yes versus no	0.90 (0.54–1.53)	0.709	2.40 (1.50–3.84)	<0.001	1.32 (0.86– 2.03)	0.201
Hormonal therapy
Yes versus no	0.70 (0.44–1.11)	0.128	0.44 (0.30–0.65)	<0.001	0.57 (0.40–0.83)	0.003
Chemotherapy
Yes versus no	1.51 (0.45–5.02)	0.502	1.36 (0.41–4.49)	0.612	0.27 (0.14–0.52)	<0.001

LVI: lymphovascular invasion.