Translational Research in Stem Cell Treatment of Neuromuscular Diseases
Figure 2
Intramuscular transplantation of genetically corrected mesoangioblasts in SCID/mdx mice. (a) Representative images showing the tibialis anterior (TA), gastrocnemius, and quadriceps muscles that received three intramuscular injections of 106 corrected mesoangioblasts. Images show engraftment of donor cells demonstrated by EGFP fluorescence (green) 3 weeks after the last injection (scale bar, 2 mm). (b) Donor cell engraftment, dystrophin production, and amelioration of morphological defects in tibialis anterior muscle from a treated SCID/mdx mouse compared with an untreated SCID/mdx mouse. Insets show Masson trichrome staining. *, , °, and # indicate strong, intermediate, weak, and no dystrophin positivity, respectively (scale bar, 100 mm). Adapted from [5].
