Translational Research in Stem Cell Treatment of Neuromuscular Diseases

Table 6

Table summarizing the clinical trials on the treatment of muscular dystrophies with stem cells.

Phase	Stem cell	Followup	Results	Reference
—	Myoblast/MPCs	1 year	No improvement in muscle strength.	[41]
—	Myoblast/MPCs	4 weeks	Allotransplantation of normal MPCs induced the expression of donor-derived dystrophin, however this expression was restricted to the sites of injection.	[42]
I	MDSCs	7 months	No local or systemic side effects were observed. Treated patients had an increased ratio of capillary per muscle fibers with a switch from slow to fast myosin-positive myofibers.	[187]
	UCBCs	100 days	Restoration of the dystrophin in muscles, and improvement of the locomotive function.	[43]