Table of Contents
ISRN Anatomy
Volume 2013, Article ID 958461, 6 pages
http://dx.doi.org/10.5402/2013/958461
Research Article

Role of Neuronal Apoptosis in Volumetric Change of Hippocampus in Diabetes Mellitus Type 1: A Predictive Model

Anatomy Department, Medicine School, North Khorasan University of Medical Sciences, Bojnurd, Iran

Received 20 May 2013; Accepted 5 July 2013

Academic Editors: V. Benagiano, A. Gonzalez-Bulnes, and M. D. P. Marcos Rabal

Copyright © 2013 Khadije Foghi and Shahriar Ahmadpour. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Pankowska, “The impact of dysglycemia on brain function in children with type 1 diabetes mellitus,” Medycyna Wieku Rozwojowego, vol. 16, no. 1, pp. 5–9, 2012. View at Google Scholar
  2. M. S. Ho, N. J. Weller, F. J. Ives et al., “Prevalence of structural central nervous system abnormalities in early-onset type 1 diabetes mellitus,” Journal of Pediatrics, vol. 153, no. 3, pp. 385–390, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. E. A. Northam, D. Rankins, and F. J. Cameron, “Therapy insight: the impact of type 1 diabetes on brain development and function,” Nature Clinical Practice Neurology, vol. 2, no. 2, pp. 78–86, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. E. A. Northam, D. Rankins, A. Lin et al., “Central nervous system function in youth with type 1 diabetes 12 years after disease onset,” Diabetes Care, vol. 32, no. 3, pp. 445–450, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. T.-J. Huang, S. A. Price, L. Chilton et al., “Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia,” Diabetes, vol. 52, no. 8, pp. 2129–2136, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Okouchi, O. Ekshyyan, M. Maracine, and Y. A. Tak, “Neuronal apoptosis in neurodegeneration,” Antioxidants and Redox Signaling, vol. 9, no. 8, pp. 1059–1096, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Aragno, R. Mastrocola, E. Brignardello et al., “Dehydroepiandrosterone modulates nuclear factor-κB activation in hippocampus of diabetic rats,” Endocrinology, vol. 143, no. 9, pp. 3250–3258, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. M. P. Witter and D. G. Amaral, The Rat Nervous System, Elsevier/Academic Press, San Diego, Calif, USA, 3rd edition, 2004.
  9. S. A. Small, M. K. Chawla, M. Buonocore, P. R. Rapp, and C. A. Barnes, “Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 18, pp. 7181–7186, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. S. H. Ahmadpour, Y. Sadegi, and H. Haghir, “Streptozotocin-induced hyperglycemia produces dark neuron in CA3 region of hippocampus in rats,” The American Journal of the Medical Sciences, vol. 1, no. 2, pp. 11–15, 2010. View at Google Scholar
  11. S. H. Ahmadpour and H. Haghir, “Diabetes mellitus type 1 induces dark neuron formation in the dentate gyrus: a study by Gallyas' method and transmission electron microscopy,” Romanian Journal of Morphology and Embryology, vol. 52, no. 2, pp. 575–579, 2011. View at Google Scholar · View at Scopus
  12. A. M. Magariños and B. S. McEwen, “Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 20, pp. 11056–11061, 2000. View at Google Scholar · View at Scopus
  13. G. Musen, K. L. In, C. R. Sparks et al., “Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry,” Diabetes, vol. 55, no. 2, pp. 326–333, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Ates, S. R. Cayli, N. Yucel et al., “Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats,” Journal of Clinical Neuroscience, vol. 14, no. 3, pp. 256–260, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. W. Scherle, “A simple method for volumetry of organs in quantitative stereology,” Mikroskopie, vol. 26, no. 1, pp. 57–60, 1970. View at Google Scholar · View at Scopus
  16. H. J. G. Gundersen and E. B. Jensen, “The efficiency of systematic sampling in stereology and its prediction,” Journal of Microscopy, vol. 147, no. 2, pp. 229–263, 1987. View at Google Scholar · View at Scopus
  17. S. H. Ahmadpour and M. A. Younesi Heravi, “Quantification of TUNEL assay in hippocampusof diabetic rats by MAT LAB: comparision with stereological method,” Journal of Clinical & Experimental Pathology, vol. 2, no. 2, 2012. View at Google Scholar
  18. J. H. Choi, I. K. Hwang, S. S. Yi et al., “Effects of streptozotocin-induced type 1diabetes on cell proliferation and neuronal differentiation in the dentate gyrus; correlation with memory impairment,” The Korean Journal of Anatomy, vol. 42, no. 1, pp. 41–48, 2009. View at Google Scholar
  19. T.-J. Huang, S. A. Price, L. Chilton et al., “Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia,” Diabetes, vol. 52, no. 8, pp. 2129–2136, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. R. J. Schulingkamp, T. C. Pagano, D. Hung, and R. B. Raffa, “Insulin receptors and insulin action in the brain: review and clinical implications,” Neuroscience and Biobehavioral Reviews, vol. 24, no. 8, pp. 855–872, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. T.-J. Huang, S. A. Price, L. Chilton et al., “Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia,” Diabetes, vol. 52, no. 8, pp. 2129–2136, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. G.-J. Biessels, A. Kamal, I. J. A. Urban, B. M. Spruijt, D. W. Erkelens, and W. H. Gispen, “Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment,” Brain Research, vol. 800, no. 1, pp. 125–135, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. K. N. Islam, M. Takahashi, S. Higashiyama et al., “Fragmentation of ceruloplasmin following non-enzymatic glycation reaction,” Journal of Biochemistry, vol. 118, no. 5, pp. 1054–1060, 1995. View at Google Scholar · View at Scopus