Individuals Diagnosed with Schizophrenia Assign Emotional Importance to Neutral Stimuli: An fMRI Study

Table 2

Brain regions activated in healthy controls and schizophrenia patients.

Group	L/R	Brain region	BA	MNI coordinates			𝑍-score	Voxels	𝑃 value
				𝑋	𝑌	𝑍
Negative minus neutral
HC minus SCZ	L	Middle temporal gyrus	20	−52	−35	−14	2.74	237	0.003
	R	Anterior temporal pole	38	56	10	−18	2.56	164	0.005
	L	Cerebellum	—	−7	−46	−49	2.56	185	0.005
Positive minus neutral
HC minus SCZ	R	Posterior cingulate gyrus	29	4	−42	14	3.06	190	0.001
	L	Middle cingulate gyrus	23	−10	−35	32	2.76	*	0.003
	L	Hippocampus	—	−35	−35	−4	2.68	30	0.04
	R	Amygdala	—	32	0	−24	2.79	9	0.017
	L	Middle temporal gyrus	20	−42	0	−28	2.74	19	0.003
	L	Precuneus	7	−13	−63	38	2.63	25	0.004
Neutral minus rest
HC minus SCZ	L	Calcarine gyrus	17	−7	−84	7	3.07	32	0.001
SZ minus HC	R	Angular gyrus	40	56	−52	24	3.19	65	0.001
	L	Middle temporal gyrus	20	−49	−10	−24	3.13	79	0.001
	L	Fusiform gyrus	20	−38	−10	−21	2.96	*	0.002
	R	Superior OFC	10	14	46	−14	3.06	22	0.001
	L	Hippocampus	—	−32	−7	−21	2.74	8	0.045
	R	Amygdala	—	32	0	−28	3.01	11	0.006
	R	Middle temporal pole	38	38	10	−32	2.76	*	0.003
	L	Middle frontal gyrus	46	−32	32	18	2.92	43	0.002
	L	Anterior cingulate gyrus	24	−7	33	10	2.78	*	0.003
	R	Middle cingulate gyrus	31	4	−28	42	2.92	53	0.002
	L	Middle cingulate gyrus	32	−10	10	35	2.69	13	0.004
	L	Superior frontal gyrus	8	−18	18	42	2.68	*	0.004
	R	Anterior cingulate gyrus	32	14	36	14	2.74	11	0.003
	L	Supplementary motor area	6	−4	−4	63	2.83	18	0.002
	L	Inferior parietal gyrus	40	−35	−42	35	2.67	6	0.004
	L	Cuneus	7	−18	−60	28	2.96	20	0.002
	R	Precentral gyrus	6	42	0	46	2.94	15	0.002
	R	Putamen	—	32	7	10	3.05	17	0.001
	L	Putamen	—	−21	10	−4	2.65	5	0.004

BA: Brodmann area, HC: healthy controls, SCZ: schizophrenia patients, OFC: orbitofrontal cortex; *brain region part of the same cluster.