Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation
Figure 4
TSLPR is essential for the development of innate type airway inflammation induced by papain. Mice were exposed daily to 25 g papain for 3 days and analyzed 24 after the last intranasal instillation. The number of eosinophils (a), lymphocytes (b), macrophages (c), and neutrophils (d) were determined in BALF as well as EPO activity in lung tissue (e) was determined 24 h after the last papain or saline control administration in wild-type (WT) and TSLPR−/− mice. Lung sections stained with Hematoxylin-Eosin (HE) (20x magnification) and score of the severity of inflammation and mucus production at 24 h after the last papain or PBS inhalation are shown (f-g). These experiments were performed twice ( mice per group). One representative experiment is shown. Values are the mean SEM of 8 mice per group.
