Table of Contents
ISRN Hypertension
Volume 2013, Article ID 980824, 9 pages
Review Article

Cardiac Effects of Exercise Training in Hypertension

Biobehavioral Research Laboratory and Department of Biobehavioral and Health Sciences, School of Nursing, University of Pennsylvania, 126 Claire M. Fagin Hall, 418 Curie Boulevard, Philadelphia, PA 19104-4217, USA

Received 29 November 2012; Accepted 18 December 2012

Academic Editors: A. A. Noorbala and A. A. Tahrani

Copyright © 2013 Joseph R. Libonati. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypertension is a significant health concern. Hypertension leads to compensatory pathologic hypertrophy and impaired cardiac function. Lifestyle modifications such as exercise are encouraged for hypertensive patients. Some studies have shown that exercise training can reverse pathological hypertrophy. Conversely, studies on animal models of hypertension have shown increased cardiac growth with exercise training. Despite the further induction of hypertrophy, exercise training seems protective against cell death and may increase cardiomyocyte proliferation, leading to a putative phenotype. One of the hallmark beneficial effects of exercise in hypertension is an improvement in myocardial β adrenergic responsiveness. The focus of this paper is to discuss how exercise training impacts cardiac remodeling and function in the hypertensive heart with specific reference to β adrenergic signaling.