Table of Contents 
ISRN Pharmaceutics
Volume 2013, Article ID 983053, 6 pages
http://dx.doi.org/10.1155/2013/983053
Research Article

Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp

Elham Khodaverdi,1 Fatemeh Kheirandish,2 Farnaz Sadat Mirzazadeh Tekie,3 Bibi Zahra Khashyarmanesh,4 Farzin Hadizadeh,5 and Hamideh Moallemzadeh Haghighi4

1Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Medical Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
4Department of Medicinal Chemistry, School of Pharmacy, Tehran University of Medical Sciences, Mashhad, Iran
5Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Received 1 October 2013; Accepted 28 October 2013

Academic Editors: S. Calis and R. Zelkó

Copyright © 2013 Elham Khodaverdi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Zhang, H. F. Chan, and K. W. Leong, “Advanced materials and processing for drug delivery: the past and the future,” Advanced Drug Delivery Reviews, vol. 65, no. 1, pp. 104–120, 2013. View at Google Scholar
  2. K. Bowey and R. J. Neufeld, “Systemic and mucosal delivery of drugs within polymeric microparticles produced by spray drying,” BioDrugs, vol. 24, no. 6, pp. 359–377, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. W. Jiang, R. K. Gupta, M. C. Deshpande, and S. P. Schwendeman, “Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens,” Advanced Drug Delivery Reviews, vol. 57, no. 3, pp. 391–410, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. C.-M. J. Hu and L. Zhang, “Nanoparticle-based combination therapy toward overcoming drug resistance in cancer,” Biochemical Pharmacology, vol. 83, no. 8, pp. 1104–1111, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. D. F. Emerich and C. G. Thanos, “The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis,” Biomolecular Engineering, vol. 23, no. 4, pp. 171–184, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Qiu and K. Park, “Environment-sensitive hydrogels for drug delivery,” Advanced Drug Delivery Reviews, vol. 53, no. 3, pp. 321–339, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. T. R. Hoare and D. S. Kohane, “Hydrogels in drug delivery: progress and challenges,” Polymer, vol. 49, no. 8, pp. 1993–2007, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. H. An, H. S. Kim, D. J. Chung, D. S. Lee, and S. Kim, “Thermal behaviour of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) tri-block copolymers,” Journal of Materials Science, vol. 36, no. 3, pp. 715–722, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Khodaverdi, A. Golmohammadian, S. A. Mohajeri, G. Zohuri, F. S. Mirzazadeh Tekie, and F. Hadizadeh, “Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) hydrogel,” ISRN Pharmaceutics, vol. 2012, Article ID 976879, 7 pages, 2012. View at Publisher · View at Google Scholar
  10. S. A. Hagan, A. G. A. Coombes, M. C. Garnett et al., “Polylactide-poly(ethylene glycol) copolymers as drug delivery systems. 1. Characterization of water dispersible micelle-forming systems,” Langmuir, vol. 12, no. 9, pp. 2153–2161, 1996. View at Google Scholar · View at Scopus
  11. L. Chen, Z. Xie, J. Hu, X. Chen, and X. Jing, “Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery,” Journal of Nanoparticle Research, vol. 9, no. 5, pp. 777–785, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Goldmints, J. F. Holzwarth, K. A. Smith, and T. A. Hatton, “Micellar dynamics in aqueous solutions of PEO-PPO-PEO block copolymers,” Langmuir, vol. 13, no. 23, pp. 6130–6133, 1997. View at Google Scholar · View at Scopus
  13. B. Jeong, Y. H. Bae, and S. W. Kim, “Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers,” Colloids and Surfaces B, vol. 16, no. 1-4, pp. 185–193, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Ahmed and D. E. Discher, “Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles,” Journal of Controlled Release, vol. 96, no. 1, pp. 37–53, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Y. Park, D. K. Han, and S. C. Kim, “Synthesis and characterization of star-shaped PLLA-PEO block copolymers with temperature-sensitive sol-gel transition behavior,” Macromolecules, vol. 34, no. 26, pp. 8821–8824, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Kumar, M. N. V. Ravikumar, and A. J. Domb, “Biodegradable block copolymers,” Advanced Drug Delivery Reviews, vol. 53, no. 1, pp. 23–44, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. A. K. Bajpai, S. K. Shukla, S. Bhanu, and S. Kankane, “Responsive polymers in controlled drug delivery,” Progress in Polymer Science, vol. 33, no. 11, pp. 1088–1118, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Hatefi and B. Amsden, “Biodegradable injectable in situ forming drug delivery systems,” Journal of Controlled Release, vol. 80, no. 1-3, pp. 9–28, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. C. B. Packhaeuser, J. Schnieders, C. G. Oster, and T. Kissel, “In situ forming parenteral drug delivery systems: an overview,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 58, no. 2, pp. 445–455, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. K. S. Anseth, A. T. Metters, S. J. Bryant, P. J. Martens, J. H. Elisseeff, and C. N. Bowman, “In situ forming degradable networks and their application in tissue engineering and drug delivery,” Journal of Controlled Release, vol. 78, no. 1-3, pp. 199–209, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. G. M. Zentner, R. Rathi, C. Shih et al., “Biodegradable block copolymers for delivery of proteins and water-insoluble drugs,” Journal of Controlled Release, vol. 72, no. 1-3, pp. 203–215, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Qiao, D. Chen, X. Ma, and Y. Liu, “Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels,” International Journal of Pharmaceutics, vol. 294, no. 1-2, pp. 103–112, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Chen and J. Singh, “Controlled release of growth hormone from thermosensitive triblock copolymer systems: in vitro and in vivo evaluation,” International Journal of Pharmaceutics, vol. 352, no. 1-2, pp. 58–65, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Qiao, D. Chen, X. Ma, and H. Hu, “Sustained release of bee venom peptide from biodegradable thermosensitive PLGA-PEG-PLGA triblock copolymer-based hydrogels in vitro,” Die Pharmazie, vol. 61, no. 3, pp. 199–202, 2006. View at Google Scholar · View at Scopus
  25. Y. J. Kim, S. Choi, J. J. Koh, M. Lee, K. S. Ko, and S. W. Kim, “Controlled release of insulin from injectable biodegradable triblock copolymer,” Pharmaceutical Research, vol. 18, no. 4, pp. 548–550, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Khodaverdi, F. S. M. Tekie, S. A. Mohajeri, F. Ganji, G. Zohuri, and F. Hadizadeh, “Preparation and investigation of sustained drug delivery systems using an injectable, thermosensitive, in situ forming hydrogel composed of PLGA-PEG-PLGA,” AAPS PharmSciTech, vol. 13, no. 2, pp. 590–600, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Chen, R. Pieper, D. C. Webster, and J. Singh, “Triblock copolymers: synthesis, characterization, and delivery of a model protein,” International Journal of Pharmaceutics, vol. 288, no. 2, pp. 207–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Yu, Z. Zhang, and J. Ding, “Influence of la and GA sequence in the PLGA block on the properties of thermogelling PLGA-PEG-PLGA block copolymers,” Biomacromolecules, vol. 12, no. 4, pp. 1290–1297, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Khodaverdi, F. Hadizadeh, F. S. M. Tekie, A. Jalali, S. A. Mohajeri, and F. Ganji, “Preparation and analysis of a sustained drug delivery system by PLGA-PEG-PLGA triblock copolymers,” Polymer Bulletin, vol. 69, no. 4, pp. 429–438, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. M. N. Silverman and E. M. Sternberg, “Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction,” Annals of the New York Academy of Sciences, vol. 1261, no. 1, pp. 55–63, 2012. View at Google Scholar
  31. N. Rohleder, J. M. Wolf, and O. T. Wolf, “Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder,” Neuroscience and Biobehavioral Reviews, vol. 35, no. 1, pp. 104–114, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Markman, V. Sheidler, and D. S. Ettinger, “Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy,” The New England Journal of Medicine, vol. 311, no. 9, pp. 549–552, 1984. View at Google Scholar · View at Scopus
  33. S. M. Grunberg, “Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: dosing, efficacy, and tolerability analysis,” Annals of Oncology, vol. 18, no. 2, pp. 233–240, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. R. E. Coleman, “Glucocorticoids in cancer therapy,” Biotherapy, vol. 4, no. 1, pp. 37–44, 1992. View at Google Scholar · View at Scopus
  35. I. Herr, E. Ucur, K. Herzer et al., “Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas,” Cancer Research, vol. 63, no. 12, pp. 3112–3120, 2003. View at Google Scholar · View at Scopus
  36. D. L. Deifenderfer, A. M. Osyczka, G. C. Reilly, and P. S. Leboy, “BMP responsiveness in human mesenchymal stem cells,” Connective Tissue Research, vol. 44, no. 1, pp. 305–311, 2003. View at Google Scholar · View at Scopus
  37. Y. Ogata, M. Yamauchi, R. H. Kim, J. J. Li, L. P. Freedman, and J. Sodek, “Glucocorticoid regulation of bone sialoprotein (BSP) gene expression—identification of a glucocorticoid response element in the bone sialoprotein gene promoter,” European Journal of Biochemistry, vol. 230, no. 1, pp. 183–192, 1995. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Martins, A. R. C. Duarte, S. Faria, A. P. Marques, R. L. Reis, and N. M. Neves, “Osteogenic induction of hBMSCs by electrospun scaffolds with dexamethasone release functionality,” Biomaterials, vol. 31, no. 22, pp. 5875–5885, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Srisawasdi and P. Pavasant, “Different roles of dexamethasone on transforming growth factor-β1-induced fibronectin and nerve growth factor expression in dental pulp cells,” Journal of Endodontics, vol. 33, no. 9, pp. 1057–1060, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. B. Alliot-Licht, G. Bluteau, D. Magne et al., “Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures,” Cell and Tissue Research, vol. 321, no. 3, pp. 391–400, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. N. Kalia and R. H. Guy, “Modeling transdermal drug release,” Advanced Drug Delivery Reviews, vol. 48, no. 2-3, pp. 159–172, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Sosnik, G. Gotelli, and G. A. Abraham, “Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: how new and how powerful,” Progress in Polymer Science, vol. 36, no. 8, pp. 1050–1078, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. A. A. Ghahremankhani, F. Dorkoosh, and R. Dinarvand, “PLGA-PEG-PLGA tri-block copolymers as in situ gel-forming peptide delivery system: effect of formulation properties on peptide release,” Pharmaceutical Development and Technology, vol. 13, no. 1, pp. 49–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Amsden, “Solute diffusion within hydrogels. Mechanisms and models,” Macromolecules, vol. 31, no. 23, pp. 8382–8395, 1998. View at Google Scholar · View at Scopus