Table of Contents
ISRN Vascular Medicine
Volume 2013, Article ID 985743, 10 pages
Research Article

Association of Leukotriene Gene Variants and Plasma LTB4 Levels with Coronary Artery Disease in Asian Indians

1Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Narayana Hrudayalaya 258/A, Bommasandra Industrial Area, Anekal Taluk, Bangalore, Karnataka 560099, India
2Thrombosis Research Institute, Bangalore 560099, India
3Thrombosis Research Institute, London, SW3 6LR, UK

Received 24 April 2013; Accepted 14 May 2013

Academic Editors: D. Guidolin, A. Mugge, B. Tesfamariam, and C.-C. Wu

Copyright © 2013 Jiny Nair et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1 shows the list of 136 functional SNPs selected for this study. This table provides information on the polymorphic status, genomic locus with associated functional property, rank based on FastSNP tool, associated literature tagging SNPs for the 136 SNPs and the 14 functional SNPs shortlisted for genotyping in the present study.

Table S2 provides the primer sequences used for the annotation of the polymorphic status of 136 SNPs.

Table S3 shows the primer sequence used for annotation of polymorphic status of the 14 functional SNPs by Tm shift method.

Table S4 demonstrates the distribution of haplotype frequency of SNPs in the study.

Table S5 provides haplotype frequency of ALOX5AP SNPs, belonging to Hap A and Hap B block.

Table S6 reports the correlation between LTB4 and lipid levels.

Figure S1 depicts linkage disequilibrium (LD) of the SNPs in ALOX5 (a), ALOX5AP (b) and LTA4H (c).

  1. Supplementary Materials
  2. Supplementary Materials