Association of Leukotriene Gene Variants and Plasma LTB4 Levels with Coronary Artery Disease in Asian Indians

Table 3

Distribution of genotypes of the short-listed SNP panel in cases and controls and estimated association with risk of CAD.

SNPs	Genotype	Frequency (number of samples)		OR (95% CI)	𝑃 value
		Control (𝑛%)	Cases (𝑛%)
ALOX5
	TT	210 (61.8%)	211 (62.4%)
rs12762303	TC	110 (32.4%)	113 (33.4%)	1.01 (0.73–1.40)	0.58
	CC	20 (5.9%)	14 (4.1%)	0.70 (0.34–1.42)
	GG	118 (34.7%)	131 (38.8%)
rs2291427	GA	169 (49.7%)	155 (45.9%)	0.83 (0.60–1.16)	0.53
	AA	53 (15.6%)	52 (15.4%)	0.89 (0.56–1.41)
	AA	212 (62.4%)	217 (64.2%)
rs1864414	AC	112 (32.9%)	109 (32.2%)	0.94 (0.68–1.30)	0.72
	CC	16 (4.7%)	12 (3.5%)	0.73 (0.34–1.59)
	CC	321 (94.4%)	318 (94.4%)
rs41314980	CA	19 (5.6%)	19 (5.6%)	1.01 (0.52–1.94)	0.98
	AA	…	…
ALOX5AP
	AA	257 (75.6%)	258 (76.8%)
rs9315050	AG	78 (22.9%)	73 (21.7%)	0.93 (0.65–1.34)	0.93
	GG	5 (1.5%)	5 (1.5%)	1.00 (0.28–3.48)
	GG	212 (62.4%)	208 (61.7%)
rs17216473	GA	115 (33.8%)	107 (31.8%)	0.95 (0.68–1.31)	0.27
	AA	13 (3.8%)	22 (6.5%)	1.72 (0.85–3.51)
	GG	280 (82.3%)	282 (83.7%)
rs17222814	GA	60 (17.6%)	52 (15.4%)	0.86 (0.57–1.29)	0.09
	AA	0 (0%)	3 (0.9%)	…
	GG	295 (86.8%)	307 (91.1%)
rs17222842	GA	43 (12.7%)	30 (8.9%)	0.67 (0.41–1.10)	0.07
	AA	2 (0.6%)	0 (0%)	…
	TT	207 (60.9%)	204 (60.4%)
rs17222919	TG	116 (34.1%)	116 (34.3%)	1.02 (0.74–1.41)	0.98
	GG	17 (5%)	18 (5.3%)	1.08 (0.54–2.15)
	CC	95 (27.9%)	85 (25.3%)
rs4769055	CA	163 (47.9%)	157 (46.7%)	1.10 (0.77–1.59)	0.48
	AA	95 (27.9%)	85 (25.3%)	1.30 (0.85–1.97)
	AA	109 (32.1%)	110 (32.5%)
rs4360791	AG	182 (53.5%)	168 (49.7%)	0.91 (0.65–1.28)	0.48
	GG	49 (14.4%)	59 (17.5%)	1.19 (0.75–1.89)
	AA	109 (32.1%)	117 (34.6%)
rs3803277	AC	181 (53.2%)	162 (47.9%)	0.83 (0.60–1.17)	0.38
	CC	50 (14.7%)	58 (17.2%)	1.08 (0.68–1.71)
	AA	261 (76.8%)	261 (77.5%)
rs1132340	AG	75 (22.1%)	72 (21.4%)	0.96 (0.67–1.39)	0.98
	GG	4 (1.2%)	4 (1.2%)	1.00 (0.25–4.06)
LTA4H
	TT	280 (82.6%)	281 (84.1%)
rs17677715	TC	55 (16.2%)	51 (15.3%)	0.92 (0.61–1.40)	0.67
	CC	4 (1.2%)	2 (0.6%)	0.50 (0.09–2.74)
	AA	169 (49.7%)	175 (52.1%)
rs2540475	GA	140 (41.2%)	135 (40.2%)	0.93 (0.68–1.28)	0.74
	GG	31 (9.1%)	26 (7.7%)	0.81 (0.46–1.42)
	AA	233 (68.5%)	244 (72.4%)
rs2247570	AG	97 (28.5%)	87 (25.8%)	0.86 (0.61–1.20)	0.41
	GG	10 (2.9%)	6 (1.8%)	0.57 (0.21–1.60)
	TT	205 (60.3%)	204 (60.5%)
rs6538697	TC	115 (33.8%)	117 (34.7%)	1.02 (0.74–1.41)	0.8
	CC	20 (5.9%)	16 (4.8%)	0.80 (0.41–1.60)
	GG	263 (77.3%)	263 (78%)
rs61937881	GA	71 (20.9%)	71 (21.1%)	1.00 (0.69–1.45)	0.60
	AA	6 (1.8%)	3 (0.9%)	0.50 (0.12–2.02)
	TT	140 (41.2%)	140 (41.5%)
rs2660898	TG	155 (45.6%)	160 (47.3%)	1.03 (0.75–1.42)	0.65
	GG	45 (13.2%)	37 (11%)	0.82 (0.50–1.35)
	GG	189 (55.6%)	183 (54.1%)
rs2660899	GT	123 (36.2%)	126 (37.3%)	1.06 (0.77–1.47)	0.92
	TT	28 (8.2%)	29 (8.6%)	1.08 (0.62–1.88)
	CC	204 (60.2%)	202 (59.8%)
rs17525495	CT	116 (34.1%)	119 (35.2%)	1.04 (0.75–1.43)	0.79
	TT	20 (5.9%)	16 (4.8%)	0.81 (0.41–1.60)
	TT	96 (28.2%)	101 (30%)
rs1978331	TC	172 (50.6%)	170 (50.5%)	0.94 (0.66–1.33)	0.79
	CC	72 (21.2%)	65 (19.4%)	0.86 (0.55–1.33)
LTC4S
	AA	234 (68.8%)	221 (65.4%)
rs730012	AC	96 (28.2%)	104 (30.8%)	1.15 (0.82–1.60)	0.65
	CC	10 (2.9%)	12 (3.6%)	1.27 (0.54–3.00)