The Medicinal Timber Canarium patentinervium Miq. (Burseraceae Kunth.) Is an Anti-Inflammatory Bioresource of Dual Inhibitors of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)

Table 3

Anti-inflammatory values of Canarium patentinervium Miq.

Extracts	Anti-inflammatory assay 5-LOX, IC50 (μg/mL)	COX-1 inhibition assay IC50 (μg/mL)	COX-2 inhibition assay IC50 (μg/mL)	COX-1/COX-2 ratio
LH	206.00±0.02	>100	>100	NA
LC	104.69±0.04	>100	>100	NA
LE	49.66±0.02	0.60±0.01	1.07±0.01	0.56
BH	110.07±0.04	>100	>100	NA
BC	29.53±0.03	>100	>100	NA
BE	59.06±0.07	11.41±0.03	9.39±0.03	1.22
NDGA	29.19±0.02	NA	NA	NA
INDO	NA	0.29±0.04	0.26±0.03	1.11

LH: leaf hexane extract, LC: leaf chloroform extract, LE: leaf ethanol extract, BH: bark hexane extract, BC: bark chloroform extract, BE: bark ethanol extract, NDGA: nordihydroguaiaretic acid, and INDO: indomethacin.
Data were obtained from three independent experiments, each performed in triplicates (𝑛=9), and represented as mean ± SD.
Values with the same letter are not significantly different (𝑃<0.05) according to Tukey, multiple comparison test.