Review Article
Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia—Current Status and Perspectives in Fetal Hemoglobin Reactivation
Table 2
Natural remedies as HbF inducer.
| Inducer | Source | Biological effects |
| Bergaptene | Aegle marmelos | Erythroid differentiation of K562 cells, HbF induction [31, 72] |
| Angelicin | Angelica arcangelica | Erythroid differentiation, HbF induction [8, 73] |
| Resveratrol | Red wine, grape skin, and darakchasava | HbF induction [8, 74] |
| Citropten and bergapten | Bergamot orange | Erythroid differentiation and HbF production [69] |
| Rapamycin | Streptomyces hygroscopicus | HbF induction [8, 13] |
| Mithramycin | Streptomyces species | HbF production [75] |
| YiSui ShengXue Granule | | Erythroid survival, proliferation, and terminal differentiation of K562 cells and HbF production [76] |
| Cucurbitacin D | Ethanol Extract of Fructus trichosanthis, which is the fruit of Trichosanthes kirilowii MAXIM | HbF production and Erythroid differentiation of K562 cells [1, 31] |
| Niprisan/Nix-0699/Nicosan | A ethanol/water extract developed in Nigeria from indigenous plants | Anti-sickling effect [31, 70, 71] |
| Terminalia catappa distilled water active fraction (TCDWF) | Terminalia catappa leaves | Erythropoiesis, cell proliferation, and transcription [77] |
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