The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer

Table 2

Univariate association of overall and disease-free survival with other variables studied.

Variables	Survival (95% CI)	P	DFS (95% CI)	P
Previous liver metastasis
No	89.2 (74.1–104.2)	0.064	70.2 (55.9–84.5)	0.017
Yes	58.8 (34.4–83.1)		35.9 (17.5–54.3)
DFI
<12 m	63.6 (31.6–75.6)	0.078	39.4 (17.6–61.2)	0.185
>12 m	89.1 (74.3–103.9)		68.5 (54.5–82.5)
<24 m	62.5 (47.8–77.1)	0.450	45.5 (31.1–59.8)	0.509
>24 m	89.4 (73.3–105.5)		69.3 (59.8–84.6)
<36 m	73.1 (57.3–80.9)	0.347	53.0 (37.8–68.2)	0.119
>36 m	95.3 (74.8–115.7)		77.5 (57.9–97.2)
<48 m	79.8 (63.6–95.9)	0.128	58.8 (43.6–74.1)	0.066
>48 m	99.1 (75.8–122.4)		81.8 (59.2–104.5)
Sex
Man	82.5 (67.5–97.6)	0.512	66.2 (50.9–81.5)	0.634
Woman	90.5 (63.9–117.1)		62.7 (39.5–85.9)
Access
VATS	84.4 (37.8–130.9)	0.880	83.1 (37.1–128.9)	0.685
Others	84.2 (70.2–98.2)		63.4 (50.4–76.4)
Complications
No	87.5 (73.2–101.7)	0.406	68.6 (55.1–82.1)	0.023
Yes	46.9 (32.1–61.8)		27.1 (7.9–46.3)
Postoperative chemotherapy
No	51.9 (36.6–67.2)	0.233	33.1 (19.2–46.9)	0.213
Yes	97.6 (81.3–113.9)		73.7 (58.2–89.3)
Lymph node involvement
−	85.8 (72.1–99.6)	0.008	67.5 (54.1–80.9)	0.001
+	61.4 (19.8–102.9)		38.6 (1.2–75.4)
Size
<1 cm	103.3 (83.4–123.3)	0.057	76.2 (48.8–103.7)	0.198
>1 cm	80.0 (66.2–93.8)		62.2 (48.9–75.4)
Number
1	95.1 (79.8–110.4)	0.001	74.9 (59.9–89.8)	0.000
>1	45.9 (29.5–62.4)		27.3 (16.1–38.5)
Age
<65 years	104.3 (83.1–125.5)	0.053	72.4 (51.9–92.8)	0.527
>65 years	70.9 (54.9–86.9)		59.6 (43.7–75.4)
Comorbidity
No	83.7 (61.6–105.8)	0.033	53.4 (35.1–71.6)	0.040
Yes	87.058 (71.8–102.4)		73.7 (56.7–90.7)
Laterality of the metastases
Right	71.4 (59.2–89.6)	0.113	54.2 (39.8–68.7)	0.050
Left	99.5 (75.2–123.3)		84.0 (61.4–106.7)
Primary
Rectum	78.3 (62.0–94.6)	0.174	60.3 (44.5–76.0)	0.319
Colon	91.9 (70.7–113.2)		71.8 (51.1–92.4)
Preoperative level of CEA
−	99.8 (82.4–117.4)	0.024	75.4 (58.2–92.7)	0.020
+	62.8 (41.1–84.6)		45.9 (25.1–66.9)

aIn all cases, time is measured in months. DFI: disease-free interval; VATS: video-assisted thoracic surgery; CEA: carcinoembryonic antigen.