Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy

Table 6

Mean percent of change of the remaining parameters after than before treatment among the studied patients with colorectal cancer receiving chemotherapy (treated with recombinant human lactoferrin and not).

Parameters	Mean percent of change (%) among the studied patients with colorectal cancer receiving chemotherapy ()		-test
	Group 1; (treated with lactoferrin); ()	Group 2; (not treated with lactoferrin); ()
CEA (ng/mL):
Range	↓98.02–↓20.83	↓89.53–400.00	3.791	0.001^*
Mean ± SD	↓−47.45 ± 20.91	95.92 ± 144.93
RBC (×10^6/microL):
Range	5.72–15.20	↓11.59–7.41	10.015	0.0001^*
Mean ± SD	11.65 ± 2.15	↓−11.65 ± 2.15
Hemoglobin (HB) (g/dL):
Range	13.91–24.72	↓23.65–9.64	8.456	0.0001^*
Mean ± SD	17.91 ± 2.76	↓−3.75 ± 9.53
WBCs (×10^3/mm^3):
Range	↓29.00–40.68	↓26.82–18.89	4.152	0.0001^*
Mean ± SD	21.51 ± 18.27	↓−1.40 ± 11.09
Platelets (×10^3/mm^3):
Range	3.43–21.94	↓39.05–8.81	7.222	0.0001^*
Mean ± SD	18.51 ± 4.56	↓−10.38 ± 14.81
Neutrophil (%):
Range	20.97–28.57	↓19.67–14.63	11.092	0.0001^*
Mean ± SD	26.31 ± 2.11	↓−1.08 ± 9.33
BUN (mg/dL):
Range	↓53.00–↓16.67	↓19.44–57.89	5.858	0.0001^*
Mean ± SD	↓−28.18 ± 10.47	7.92 ± 21.44
Serum creatinine (mg/dL):
Range	↓40.00–100	↓16.67–70.73	1.596	0.122
Mean ± SD	↓−5.24 ± 37.15	13.03 ± 24.20
AST (IU/L):
Range	↓62.07–↓17.60	↓53.85–89.87	3.757	0.001^*
Mean ± SD	↓−27.50 ± 15.13	4.63 ± 29.46
ALT (IU/L):
Range	↓32.23–155.56	−23.19–28.71	0.755	0.457
Mean ± SD	↓−5.66 ± 46.83	3.97 ± 15.96

Note: ^*significant ().