1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship
Figure 7
Structures of some DHP receptor modulators: (a) (S)-Bay K8644 (agonist); (b) (R)-Bay K8644 (antagonist); (c) amlodipine; (d) dihydropyrimidine (general structure); (e) highly active compound with phenyl substituent at C-6 position; and (f) 1,4-DHPs general structure showing the orientation of affinity axis (axis 1) and chirality-activity axis (axis 2) on the boat conformation.
