International Scholarly Research Notices / 2014 / Article / Fig 8

Research Article

1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship

Figure 8

DHP receptor active site. (a) DHP sensing residues and calcium ion; (b) affinity axis passes through Try1149 (H-bond site) and Tyr1460 (ring to ring interaction site); chirality-activity axis (axis 2) passes through water lake and calcium and hydrophobic bracelet (Leu397, Leu745, Met 1185, and Ile1468).

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