1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship

Figure 8

DHP receptor active site. (a) DHP sensing residues and calcium ion; (b) affinity axis passes through Try¹¹⁴⁹ (H-bond site) and Tyr¹⁴⁶⁰ (ring to ring interaction site); chirality-activity axis (axis 2) passes through water lake and calcium and hydrophobic bracelet (Leu³⁹⁷, Leu⁷⁴⁵, Met ¹¹⁸⁵, and Ile¹⁴⁶⁸).

(a)

(b)