International Scholarly Research Notices / 2014 / Article / Tab 1

Research Article

1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship

Table 1

Amino acid sequences of L-type voltage-gated Ca2+ channel alpha-1C and potassium channel (KcsA) used for homology modeling of DHP receptor.

S5

KcsA23ALHWRAAGAATVLLVIVLLAGSYLAVLAER GAP GAA-
Repeat I262I KAMVP L LH IALLVLFVI I IYAI I G LELFM GKMHKT-
Repeat II645LNS VR S I A S L LLLLF LFI I I FSLLGMQLFGGKFNFDE
Repeat III1023FVA I R T I G N I VIVTT LLQFM FACI GVQLF KGKLYTC-
Repeat IV1354I KS FQ A LP YV ALLIV MLFF I YAVI GMQVFGKIALNDT

P-loop

KcsA59L I SYPDALWW SVETATTVGYGDLY P VT - - -
Repeat I298CYN342GI TNF D N FAFAMLTVFQC I TMEGWTDVL YWVNDAVG R
Repeat II682MQTRRSTF D N FPQS L LTVFQ I LT G EDWNSVMYD G I MAYGGPSFPG - - - -
Repeat III1059SDSSK1096FDF D N VLAAMMALFTVS T F EGWP ELL Y R S I D S HTEDKGPIYNYR
Repeat IV1391T E INRNNN FQ TF PQA V LLLFRC AT GEAWQDI ML ACM PGKK CAPESEPSNSTEGETPCGS

S6

KcsA86LWGRCVAVVVMVAGITSYGLV FAAVATWF V GREQ
Repeat I379DWPWIY FV T L I II GSFFVLNLVLGV LS G E FSKERE
Repeat II727MLVC IY F I I L F I CGNYILLNVFLA I AV D N LADAE
Repeat III1140V E I S IF F I IYI III AFFMMNIFVGFVIVTFQEQG
Repeat IV1450SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLT

(i) Residue number is in the left of one letter code for the first residue and site of exclusion.
(ii) Active site residues are bold and underlined.

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