1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship

Table 1

Amino acid sequences of L-type voltage-gated Ca²⁺ channel alpha-1C and potassium channel (KcsA) used for homology modeling of DHP receptor.

S5
KcsA	23	ALHWRAAGAA	TVLLVIVLLA	GSYLAVLAER	GAP GAA-
Repeat I	262	I KAMVP L LH I	ALLVLFVI I I	YAI I G LELFM	GKMHKT-
Repeat II	645	LNS VR S I A S L	LLLLF LFI I I	FSLLGMQLFG	GKFNFDE
Repeat III	1023	FVA I R T I G N I	VIVTT LLQFM	FACI GVQLF K	GKLYTC-
Repeat IV	1354	I KS FQ A LP YV	ALLIV MLFF I	YAVI GMQVFG	KIALNDT
P-loop
KcsA	59	L I SYPDALWW	SVETATTVGY	GDLY P VT - - -
Repeat I	298	CYN^342GI TNF D N	FAFAMLTVFQ	C I TMEGWTDV	L YWVNDAVG R
Repeat II	682	MQTRRSTF D N	FPQS L LTVFQ	I LT G EDWNSV	MYD G I MAYGG	PSFPG - - - -
Repeat III	1059	SDSSK^1096FDF D N	VLAAMMALFT	VS T F EGWP EL	L Y R S I D S HTE	DKGPIYNYR
Repeat IV	1391	T E INRNNN FQ	TF PQA V LLLF	RC AT GEAWQD	I ML ACM PGKK	CAPESEPSNS	TEGETPCGS
S6
KcsA	86	LWGRCVAVVV	MVAGITSYGL	V FAAVATWF V	GREQ
Repeat I	379	DWPWIY FV T L	I II GSFFVLN	LVLGV LS G E F	SKERE
Repeat II	727	MLVC IY F I I L	F I CGNYILLN	VFLA I AV D N L	ADAE
Repeat III	1140	V E I S IF F I IY	I III AFFMMN	IFVGFVIVTF	QEQG
Repeat IV	1450	SFAVFYFISF	YMLCAFLIIN	LFVAVIMDNF	DYLT

(i) Residue number is in the left of one letter code for the first residue and site of exclusion.
(ii) Active site residues are bold and underlined.