Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective
Table 1
A system of classification for FDA approved local hemostats, sealants, and adhesives in 2013. The fibrin sealants are in bold font [45], adapted and reprinted with kind permission of the Southeastern Surgical Congress in [45, page 1306, Table ].
Group
Category
Class
Hemostats
Mechanical
Porcine gelatin
Bovine collagen
Oxidized regenerated cellulose
Polysaccharide spheres
Active
Bovine thrombin
Human pooled plasma thrombin with or without porcine gelatin sponge or powder
Recombinant human thrombin
Flowable
Bovine gelatin and human pooled plasma thrombin
Porcine gelatin ± thrombin
Fibrin sealant
Human pooled plasma liquid
Individual human plasma liquid, bovine collagen, and bovine thrombin
Human pooled plasma and equine collagen patch
Human pooled plasma and oxidized regenerated cellulose patch
Sealants
Fibrin sealant
Human pooled plasma liquid
Polyethylene glycol polymer (PEG)
Two PEGs
PEG, trilysine amine, and FD&C Blue #1
PEG and human serum albumin
Albumin & glutaraldehyde
Bovine serum albumin and 10% glutaraldehyde
Cyanoacrylate
Octyl and butyl lactoyl cyanoacrylate
Adhesives
Cyanoacrylate
Octyl cyanoacrylate with FD&C Violet #2
Octyl cyanoacrylate with FD&C Violet #2 and polyester mesh
Butyl cyanoacrylate with or without FD&C Violet #2
