Table 1: A system of classification for FDA approved local hemostats, sealants, and adhesives in 2013. The fibrin sealants are in bold font [45], adapted and reprinted with kind permission of the Southeastern Surgical Congress in [45, page 1306, Table ].

GroupCategoryClass

HemostatsMechanicalPorcine gelatin
Bovine collagen
Oxidized regenerated cellulose
Polysaccharide spheres
ActiveBovine thrombin
Human pooled plasma thrombin with or without porcine gelatin sponge or powder
Recombinant human thrombin
FlowableBovine gelatin and human pooled plasma thrombin
Porcine gelatin ± thrombin
Fibrin sealantHuman pooled plasma liquid
Individual human plasma liquid, bovine collagen, and bovine thrombin
Human pooled plasma and  equine collagen patch
Human pooled plasma and oxidized regenerated cellulose patch

SealantsFibrin sealantHuman pooled plasma liquid
Polyethylene glycol polymer (PEG)Two PEGs
PEG, trilysine amine, and FD&C Blue #1
PEG and human serum albumin
Albumin & glutaraldehyde Bovine serum albumin and 10% glutaraldehyde
CyanoacrylateOctyl and butyl lactoyl cyanoacrylate

AdhesivesCyanoacrylateOctyl cyanoacrylate with FD&C Violet #2
Octyl cyanoacrylate with FD&C Violet #2 and polyester mesh
Butyl cyanoacrylate with or without FD&C Violet #2
Albumin & glutaraldehyde Bovine serum albumin and 10% glutaraldehyde
Fibrin sealantHuman pooled plasma liquid