Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 209683, 6 pages
Research Article

Alterations of Blood Pressure and ECG following Two-Week Consumption of Berberis integerrima Fruit Extract

1Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, P.O. Box 7616914115, Kerman, Iran

Received 28 August 2014; Revised 26 September 2014; Accepted 2 October 2014; Published 30 October 2014

Academic Editor: Don Poldermans

Copyright © 2014 Siyavash Joukar and Naser Mahdavi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In light of the popularity and also the various nutritional and medicinal properties of Berberis integerrima, this study was conducted to assess the influence of its aqueous extract on hemodynamic and electrocardiogram (ECG) indices of rat. Animals were divided to control (CTL), B50, B100, and B200 groups that orally received tap water, aqueous extracts of B. integerrima fruit 50, 100, and 200 mg/kg/day, respectively, for two weeks and on day 15, data were recorded. Different doses of barberry fruit extract had no significant effect on blood pressure, heart rate, RR interval, P duration, and Q wave amplitude of electrocardiogram. Extract administration was associated with an incremental trend in PR interval that was not statistically significant. Higher doses (100 and 200 mg/kg) of extract significantly increased the QRS interval ( versus CTL and B50 groups) but decreased the QTc interval ( versus CTL group and versus B50 group), the JT interval, and TpTe interval ( versus CTL and B50 groups). The results suggest that high doses of barberry extract definitely prolong the depolarization phase and shorten the repolarization phase of ventricular muscle and hence induce alteration in heart electrical conductivity.