Doxapram Hydrochloride Aggravates Adrenaline-Induced Arrhythmias Accompanied by Bidirectional Ventricular Tachycardia
Table 1
Changes in ECG parameters.
Cont
Dox
Adr
Pre BVT
RR
213.8 ± 13.5
188.8 ± 10.0*
188.1 ± 17.3*
166.0 ± 10.7**
QT
85.0 ± 10.2
84.9 ± 7.8
89.1 ± 7.5
94.4 ± 10.6
QTc
141.8 ± 16.6
148.0 ± 13.0
155.5 ± 11.6
172.1 ± 20.1*
JT
64.0 ± 11.3
63.5 ± 8.5
67.4 ± 9.5
72.0 ± 10.6
JTc
106.4 ± 18.7
110.6 ± 14.4
117.6 ± 14.9
131.3 ± 19.7*
JTp
7.1 ± 2.9
10.1 ± 2.8
11.8 ± 3.9*
22.2 ± 4.6**
JTpc
11.8 ± 4.8
17.5 ± 4.8
20.6 ± 7.1*
40.5 ± 8.4**
Tp-e
56.9 ± 10.1
53.4 ± 7.9
55.6 ± 9.4
49.8 ± 7.1
Tp-ec
95.0 ± 16.1
93.1 ± 13.5
97.0 ± 14.7
90.8 ± 13.4
Values are shown as the mean (ms) ± SD. (compared with control); (compared with all others) . Cont: control, Dox: doxapram hydrochloride, Adr: adrenaline, and pre BVT: just before the ventricular tachycardia (calculated from the narrow QRS complex). Tp-e: T peak to T end interval, Tp-ec: corrected Tp-e interval.
