Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 214026, 12 pages
Research Article

Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films

1Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh 201313, India
2Department of Pharmaceutics, B. S. Anangpuria Institute of Pharmacy, Faridabad, India
3Department of Pharmaceutics, Kota College of Pharmacy, Kota, India

Received 27 May 2014; Accepted 16 September 2014; Published 30 October 2014

Academic Editor: Anuradha Mishra

Copyright © 2014 Upendra Nagaich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the present study was to prepare unidirectional buccal films of buspirone hydrochloride by solvent casting technique. Hydroxypropylmethylcellulose (HPMC K15M) and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 and sodium lauryl sulphate were used as plasticizer and permeation enhancer, respectively, in different concentration. In the formulation, total amount of polymer (X1) and percentage of HPMC K15M (X2) were kept as independent variables. Afterwards, statistically optimized process was carried out and two optimized formulations (OF1 and OF2) were developed. The observed results of optimized formulation were showed a greater degree of percentage of similarity with predicted values. The stability studies showed that there was no significant change found in physicochemical properties, in-vitro release, and ex-vivo diffusion studies.