Table of Contents
ISRN Polymer Science
Volume 2014 (2014), Article ID 241297, 5 pages
Research Article

Natural Rubber Latex: Study of a Novel Carrier for Casearia sylvestris Swartz Delivery

1School of Science and Letters of Assis, Department of Biological Sciences, São Paulo State University, 210 Dom Antônio Avenue, 19806-900 Assis, SP, Brazil
2School of Pharmaceutical Sciences, Department of Natural Principles and Toxicology, São Paulo State University, Araraquara-Jaú Road, Km 01, 14801-902 Araraquara, SP, Brazil
3School of Sciences of Bauru, Department of Physics, São Paulo State University, 14-01 Luiz Edmundo Carrijo Coube Avenue, 17033-360 Bauru, SP, Brazil
4Institute of Chemistry of Araraquara, São Paulo State University, 55 Professor Francisco Degni Street, 14800-900 Araraquara, SP, Brazil

Received 30 October 2013; Accepted 24 December 2013; Published 12 February 2014

Academic Editors: H.-L. Chen, P. Dobrzynski, and S. Yamazaki

Copyright © 2014 Felipe Azevedo Borges et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Natural rubber latex (NRL) from Hevea brasiliensis has showed interesting biomedical properties as improving wound healing, cell adherence, tissue formation, and angiogenesis. It is used for biosynthesis of nanoparticles, sensors and prosthesis and for drug delivery systems (for drugs, plant extracts, and nanoparticles). To enhance its wound healing properties was incorporated Casearia sylvestris Swartz extract, whose pharmacological activity includes anti-inflammatory, analgesic, antiseptic, antiulcer, and antitumor due to its casearins and phenols. Results showed the prolonged release of its compounds (35 days) and the mechanism of release is super case II ( ) by Korsmeyer-Peppas model. Although SEM shows different sizes of clusters at the surface, the release is homogeneous through the biomembrane. FTIR shows no interaction between the matrix and the extract, with computation of the presence of some casearins.