Formulation Development and Optimization of Fast Dissolving Tablets of Aceclofenac Using Natural Superdisintegrant

Table 3

Evaluation of precompression parameters of factorial design batches of Aceclofenac fast dissolving tablets.

Parameter	D1	D2	D3	D4	D5	D6	D7	D8	D9
Bulk density (g/mL)	0.481±0.023	0.484±0.014	0.458±0.021	0.514±0.040	0.515±0.041	0.504±0.029	0.482±0.025	0.484±0.043	0.514±0.009
Tapped density (g/mL)	0.584±0.013	0.548±0.023	0.550±0.020	0.587±0.009	0.589±0.018	0.590±0.021	0.570±0.015	0.556±0.019	0.605±0.040
Angle of repose	20.30±0.21	24.70±0.13	21.30±0.25	22.78±0.32	22.79±0.08	21.30±0.15	22.29±0.22	23.74±0.09	25.64±0.25
Carr’s index	17.6	11.7	16.6	12.5	12.8	14.06	15.2	12.9	15.0
Hausner ratio	1.21	1.13	1.20	1.14	1.14	1.17	1.18	1.14	1.17

Data are represented as mean ± SD (𝑛=3).