Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

Table 1

Effect of dried pulp of Aloe succotrina leaves on body weight of HFD-induced hyperlipidemic rats.

Group; number	Treatment; (p.o.)	Dose; (kg^−1)	Number; of animals	Body weight (g)
				Week 0	Week 1	Week 2	Week 3	Week 4
1	Vehicle (1% w/v CMC)	10 mL	6	83.16±3.98	87.66±4.09	95.5±3.77	103.33±4.82	104.33±4.78
2	Vehicle (1% w/v CMC) + HFD	10 mL	6	82.33±2.96	102.16±3.19^a	112.66±4.73^c	129.66±5.90^c	136.00±5.75^c
3	Atorvastatin + HFD	10 mg	3	83.00±4.44	98.16±5.16	118.16±8.37	124.00±8.09	133.33±11.86
4	Aloe succotrina + HFD	100 mg	5	79.16±3.92	101.83±5.134	124.5±5.74	106.66±5.48	115.8±16.33
5	Aloe succotrina + HFD	200 mg	5	81.83±5.13	104.00±7.17	129.83±8.25	138.83±6.98	150.6±7.36

In each group; values are in Mean ± SEM; data were analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
F (4, 25) = 21.29; 𝑃<0.0001 (for HFD treated control from week 0 to week 4).
F (4, 25) = 1.636; 𝑃<0.1964 (comparison among various groups at week 1).
F (4, 25) = 4.207; 𝑃<0.0097 (comparison among various groups at week 2).
F (4, 25) = 5.585; 𝑃<0.0024 (comparison among various groups at week 3).
F (4, 20) = 7.901; 𝑃<0.0005 (comparison among various groups at week 4).
^a𝑃<0.05 and ^c𝑃<0.001 as compared to HFD treated control (week 0).