|
| Authors, journal, year of publication | Methods | Percentage of patients with CCR5 tropic virus (median) | Total number of patients |
|
| Acute and early HIV infection |
| Eshleman et al. [17], AIDS Res Hum Retroviruses 2007 | Phenotypic (replication-defective retroviral vector assay) | 98 | 195 |
| Huang et al. [18], AIDS Res Hum Retroviruses 2009 |
Trofile | 96 | 150 |
| Frange et al. [19], J. Clin. Microbiol. 2010 | Geno2PhenoFPR 10%
Phenotypic (recombinant virus entry assay) | 88% | 131 |
| Frange et al. [20], J. Antimicrob. Chemother. 2009 | Genotypic (5 genotypic rules to predict tropism) | 84% | 390 |
| De Mendoza et al. [21], J. Antimicrob. Chemother. 2007 | Genotypic (wetcat prediction algorithm) | 83% | 203 |
| Rieder et al. [22], Clin. Infect. Dis. 2011 | Genotypic with 3 prediction tools (web-PSSM, wetcat, Geno2Pheno)
Phenotypic (MT2 and GHOST cell culture assays) | 90%, 81%, 86% | 145 |
| Chalmet et al. [23], J. Infect. Dis. 2012 | Geno2Pheno | 81–88% | 539 |
| Raymond et al. [24], AIDS 2010 | Recombinant virus phenotypic entry assay (Toulouse tropism test assay) | 93.6% |
133 |
| Geno2Pheno | 88% |
| Hamlyn et al. [25], AIDS 2012 | Geno2PhenoFPR 5.75% | 91.7% | 120 |
| Nozza et al. [26], J. Acquir. Immune Defic. Syndr. 2014 | plasma,
PBMC
| 87.3% |
66 |
| PSSMx4r5 | 87% |
| (ds) kernel | 92.4% |
| Charpentier et al. [27], J. Antimicrob. Chemother. 2013 | on HIV RNA | 60% |
170 |
| on HIV DNA | 54% |
| Nozza et al. [28], J. Antimicrob. Chemother. 2012 | | 86% | 223 |
| Simon et al. [42], AIDS 2010 | | 62% | 50 |
| Moyle et al. [29], J. Infect. Dis. 2005 | ViroLogic PhenoSense assay | 81% | 402 |
| Santoro et al. [31], Clin. Microbiol. Infect 2012 | Geno2PhenoFPR 2% | 4.9% |
532 |
| 25% |
|
| Experienced HIV patients |
| Gulick et al. [4], N Engl J Med 2008 | Trofile | 70% | 1049 |
| Caseiro et al. [43], J. Infect. 2012 | Trofile | 84% | 857 |
|
Recordon-Pinson et al. [44], Antimicrob. Agents Chemother. 2010 | Trofile | 71.4% |
236 |
| Geno2PhenoFPR10% | 77% |
| Svicher et al. [45], New Microbiol. 2010 | Trofile | 76.5% |
406 |
| Geno2PhenoFPR10% | 70% |
|
