Formulation Development and Characterization of Meclizine Hydrochloride Sublimated Fast Dissolving Tablets

Table 1

Formulations of meclizine hydrochloride FDTs by sublimation method.

Ingredients (mg)	F1	F2	F3	F4	F5	F6	F7	F8	F9
Meclizine HCl	25	25	25	25	25	25	25	25	25
Sodium starch glycolate	2	4	6	—	—	—	—	—	—
Croscarmelose sodium	—	—	—	2	4	6	—	—	—
Crospovidone	—	—	—	—	—	—	2	4	6
Camphor	10	10	10	10	10	10	10	10	10
Microcrystalline cellulose	59	57	55	59	57	55	59	57	55
Aspartame	1	1	1	1	1	1	1	1	1
Magnesium stearate	1	1	1	1	1	1	1	1	1
Talc	2	2	2	2	2	2	2	2	2
Total tablet weight	100	100	100	100	100	100	100	100	100