Table of Contents
ISRN Nanotechnology
Volume 2014, Article ID 287575, 13 pages
Research Article

Treatment of Anemia Progression via Magnetite and Folate Nanoparticles In Vivo

1Department of Nutrition Chemistry and Metabolism, National Nutrition Institute (NNI)—Healthy Minster, 16 Kasr El Aini Street, Cairo 11441, Egypt
2Department of Measurements, Photochemistry and Agriculture Applications, National Institute of Laser Enhanced Science (NILES), Cairo University, Giza 11562, Egypt
3Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Cairo 11562, Egypt
4Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 11562, Egypt

Received 21 October 2013; Accepted 9 January 2014; Published 4 March 2014

Academic Editors: Q. Chen, H. Duan, and K. H. Park

Copyright © 2014 Hanaa Hussein Elsayed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Iron deficiency anemia is a major global public health problem. Food fortification with iron (Fe) can be an effective strategy to control iron deficiency. An iron oxide nanoparticle (NP) is a new physical and chemical property form. These properties (small particle size, unique physical properties) make nanoiron a great scientific interest especially in the treatment of anemia. The study aimed to reduce anemia by nanoparticles (NPs). Forty-eight adult female Sprague-Dewily rats were divided into four groups (12 rats each). Group A represented a negative control. Other groups were fed standard diet iron free and three time of require zinc to reach anemic. Group B fed standard diet with ferrous sulfate until the improvement of the situation of anemia or for 8 weeks. Groups C and D were divided into three subgroups; each subgroup was fed a dose from magnetite or folate coated magnetite NPs. Results showed that symptoms of loss of appetite and severe lethargy demonstrate that magnetite and folate-coated magnetite nanoparticles have serious toxicological effects in vivo. Some doses from NPs improve blood picture during 2 weeks but change in histopathology examinations were occur in some groups within 2 weeks. Nanoparticles were considered the toxicological hazards especially the size of less than 54 nm.