Table of Contents
ISRN Oncology
Volume 2014 (2014), Article ID 289836, 7 pages
http://dx.doi.org/10.1155/2014/289836
Clinical Study

Vinorelbine with or without Trastuzumab in Metastatic Breast Cancer: A Retrospective Single Institution Series

1Department of Oncology, University Hospital of Lausanne (CHUV), 1011 Lausanne, Switzerland
2Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, 750 Great Northern Road, Sault Ste Marie, ON, Canada P6B OA8

Received 19 February 2014; Accepted 12 March 2014; Published 30 March 2014

Academic Editors: A. E. Bilsland and D. Niino

Copyright © 2014 Athina Stravodimou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. N. Hortobagyi, J. de la Garza Salazar, K. Pritchard et al., “The global breast cancer burden: variations in epidemiology and survival,” Clinical Breast Cancer, vol. 6, no. 5, pp. 391–401, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. K. S. Albain, J. de la Garza Salazar, T. Pienkowski et al., “Reducing the global breast cancer burden: the importance of patterns of care research,” Clinical Breast Cancer, vol. 6, no. 5, pp. 412–420, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. E. K. Rowinski, “Antimicrotubule agents,” in Cancer Chemotherapy and Biotherapy, B. A. Chabner and D. L. Longo, Eds., pp. 240–253, Lippincott Williams and Wilkins, Philadelphia, Pa, USA, 2006. View at Google Scholar
  4. D. P. Malinowski, “Multiple biomarkers in molecular oncology. II. Molecular diagnostics applications in breast cancer management,” Expert Review of Molecular Diagnostics, vol. 7, no. 3, pp. 269–280, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. D. J. Slamon, B. Leyland-Jones, S. Shak et al., “Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2,” The New England Journal of Medicine, vol. 344, no. 11, pp. 783–792, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Valero, J. Forbes, M. D. Pegram et al., “Multicenter phase III randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-gene-amplified metastatic breast cancer (BCIRG 007 Study): two highly active therapeutic regimens,” Journal of Clinical Oncology, vol. 29, no. 2, pp. 149–156, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. E. A. Eisenhauer, P. Therasse, J. Bogaerts et al., “New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1),” European Journal of Cancer, vol. 45, no. 2, pp. 228–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Cardoso, P. L. Bedard, E. P. Winer et al., “International guidelines for management of metastatic breast cancer: combination vs sequential single-agent chemotherapy,” Journal of the National Cancer Institute, vol. 101, no. 17, pp. 1174–1181, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Capasso, “Vinorelbine in cancer therapy,” Current Drug Targets, vol. 13, no. 8, pp. 1065–1071, 2012. View at Publisher · View at Google Scholar
  10. M. Aapro and J. Finek, “Oral vinorelbine in metastatic breast cancer: a review of current clinical trial results,” Cancer Treatment Reviews, vol. 38, no. 2, pp. 120–126, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Fan, B. Cherney, W. Reinhold, K. Rucker, and P. M. O'Connor, “Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment,” Clinical Cancer Research, vol. 4, no. 4, pp. 1047–1054, 1998. View at Google Scholar · View at Scopus
  12. A. Krikorian, R. Rahmani, M. Bromet, P. Bore, and J. P. Cano, “Pharmacokinetics and metabolism of navelbine,” Seminars in Oncology, vol. 16, supplement 4, pp. 21–25, 1989. View at Google Scholar · View at Scopus
  13. M. Martín, A. Ruiz, M. Muñoz et al., “Gemcitabine plus vinorelbine versus vinorelbine monotherapy in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: final results of the phase III Spanish Breast Cancer Research Group (GEICAM) trial,” The Lancet Oncology, vol. 8, no. 3, pp. 219–225, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Toi, T. Saeki, K. Aogi et al., “Late phase II clinical study of vinorelbine monotherapy in advanced or recurrent breast cancer previously treated with anthracyclines and taxanes,” Japanese Journal of Clinical Oncology, vol. 35, no. 6, pp. 310–315, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Y. Seo, H. J. Lee, O. H. Woo et al., “Phase II study of vinorelbine monotherapy in anthracycline and taxane pre-treated metastatic breast cancer,” Investigational New Drugs, vol. 29, no. 2, pp. 360–365, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Freyer, T. Delozier, M. Lichinister et al., “Phase II study of oral vinorelbine in first-line advanced breast cancer chemotherapy,” Journal of Clinical Oncology, vol. 21, no. 1, pp. 35–40, 2003. View at Google Scholar · View at Scopus
  17. M. Andersson, E. Lidbrink, K. Bjerre et al., “Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the HERNATA study,” Journal of Clinical Oncology, vol. 29, no. 3, pp. 264–271, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Heinemann, D. di Gioia, U. Vehling-Kaiser et al., “A prospective multicenter phase II study of oral and i.v. vinorelbine plus trastuzumab as first-line therapy in HER2-overexpressing metastatic breast cancer,” Annals of Oncology, vol. 22, no. 3, pp. 603–608, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. E. de Maio, C. Pacilio, A. Gravina et al., “Vinorelbine plus 3-weekly trastuzumab in metastatic breast cancer: a single-centre phase 2 trial,” BMC Cancer, vol. 7, article 50, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. R. Lee, S. J. Huh, D. H. Lee et al., “Phase II study of vinorelbine plus trastuzumab in HER2 overexpressing metastatic breast cancer pretreated with anthracyclines and taxanes,” Journal of Breast Cancer, vol. 14, no. 2, pp. 140–146, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Redana, M. Donadio, F. Nolè et al., “Trastuzumab with either docetaxel or vinorelbine as first-line treatment for patients with HER2-positive advanced breast cancer: a retrospective comparison,” BMC Cancer, vol. 10, article 28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Montemurro, S. Redana, F. Nolè et al., “Vinorelbine-based salvage therapy in HER2-positive metastatic breast cancer patients progressing during trastuzumab-containing regimens: a retrospective study,” BMC Cancer, vol. 8, article 209, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Bartsch, U. Pluschnig, C. Wenzel et al., “Oral vinorelbine in metastatic breast cancer—the Vienna experience,” Annals of Oncology, vol. 19, supplement 8, article viii71, 2008. View at Google Scholar
  24. P. Papaldo, A. Fabi, G. Ferretti et al., “A phase II study on metastatic breast cancer patients treated with weekly vinorelbine with or without trastuzumab according to HER2 expression: changing the natural history of HER2-positive disease,” Annals of Oncology, vol. 17, no. 4, pp. 630–636, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Bartsch, C. Wenzel, G. Altorjai et al., “Results from an observational trial with oral vinorelbine and trastuzumab in advanced breast cancer,” Breast Cancer Research and Treatment, vol. 102, no. 3, pp. 375–381, 2007. View at Publisher · View at Google Scholar · View at Scopus