Total Ischemic Time as an Independent Predictor of Response to Stem Cell Therapy in Patients with ST Segment Elevation Myocardial Infarction

Table 3

(a) Subgroup characteristics of studies. (b) Subgroup characteristics of baseline and post-PCI measurements of LV parameters.

(a)

	Subgroups	Trial	Patient number		SC dose*; (10^6)	Followup*; (months)	Time to PCI*(hours)		SC delivery; Time* (days)
			BMSC	Placebo			BMSC	Placebo
Short term	PCI < 6 (hours)
	EF < 45%	Penicka et al., 2007 +++++ [17]	113	69	523.4	5.7	5.0	4.9	6.7
		Tendera et al., 2009 REGENT [4]
		Piepoli et al., 2010 [18]
	EF ≥ 45%	Janssens et al., 2006 [2]	204	184	219.2	4.7	4.2	4.2	4.2***
		Schächinger et al., 2006 REPAIR-AMI [8]
		Lunde et al., 2006 ASTAMI [3]
		Grajek et al., 2010 [5]
	PCI ≥ 6 (hours)
	EF < 45%	Meluzín et al., 2008 [16]	58	38	128.8	6.0	7.1	8.6	6.9
		Plewka et al., 2009 [12]
	EF ≥ 45%	Wollert et al., 2004 BOOST [6]	104	85	3684.5**	6.0	8.2	7.5	9.0
		Chen et al., 2004 [9]
		Ge et al., 2006 TCT-STAMI [10]
		Traverse et al., 2010 [19]
Long term	PCI < 6 (hours)
	EF < 45%	Piepoli et al., 2010 [18]	19	19	418	12	4.1	4.4	4.0
	EF ≥ 45%	Beitnes et al., 2009 ASTAMI [21]	81	64	198.9	28.6	4.0	3.7	5.6***
		Grajek et al., 2010 [5]
	PCI ≥ 6 (hours)
	EF < 45%	Meluzín et al., 2008 [16]	20	20	100	12	7.2	9.2	6.8
	EF ≥ 45%	Meyer et al., 2006 BOOST [20]	118	125	709.5	38	9.4	8.7	5.9
		Yousef et al., 2009 BALANCE [22]
		Assmus et al., 2010 REPAIR-AMI CMR-Subs [23]

∗Weighted means.
**There was no stated mean value in Chen et al., 2004 [9]. A rough mean value of 9×10⁶ was taken for weighted means.
***Grajek et al., 2010 [5]. SC delivery time of 5 was used.

(b)

	Subgroups	Trial	Patient number		Baseline; LVEF* (percent)		Post-PCI; LVEF (percent)		Baseline; LVESV (mL/m²)		Post-PCI; LVESV (mL/m^2)
			BMSC	Placebo	BMSC	Placebo	BMSC	Placebo	BMSC	Placebo	BMSC	Placebo
Short term	PCI < 6 (hours)
	EF < 45%	Penicka et al., 2007 +++++ [17]	113	69	37.2	38.6	41.5	40.4	90.7	85.7	89.3	91.1
		Tendera et al., 2009 REGENT [4]
		Piepoli et al., 2010 [18]
	EF ≥ 45%	Janssens et al., 2006 [2]	204	184	50.1	48.8	53.1	51.3	69.6	75.1	68.8	77.1
		Schächinger et al., 2006 REPAIR-AMI [8]
		Lunde et al., 2006 ASTAMI [3]
		Grajek et al., 2010 [5]
	PCI ≥ 6 (hours)
	EF < 45%	Meluzín et al., 2008 [16]	58	38	36.7	36.7	45	39.1	100	96	95	105
		Plewka et al., 2009 [12]
	EF ≥ 45%	Wollert et al., 2004 BOOST [6]	104	85	49.8	50.4	59.8	53.9	46	40	39	38
		Chen et al., 2004 [9]
		Ge et al., 2006 TCT-STAMI [10]
		Traverse et al., 2010 [19]
Long term	PCI < 6 (hours)
	EF < 45%	Piepoli et al., 2010 [18]	19	19	36.6	37.5	46.1	41	80.1	76.5	67.6	76
	EF ≥ 45%	Beitnes et al., 2009 ASTAMI [21]	81	64	53.1	52.9	51.9	52.8	73	75.8	78.1	77.6
		Grajek et al., 2010 [5]
	PCI ≥ 6 (hours)
	EF < 45%	Meluzín et al., 2008 [16]	20	20	40	40	47	40	100	96	97	113
	EF ≥ 45%	Meyer et al., 2006 BOOST [20]	118	125	49.8	50.4	55.1	47.8	75.3	73.7	71.7	93.8
		Yousef et al., 2009 BALANCE [22]
		Assmus et al., 2010 REPAIR-AMI CMR-Subs [23]

∗Weighted means.