Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 307064, 7 pages
http://dx.doi.org/10.1155/2014/307064
Review Article

Disease Modifying Therapy in Multiple Sclerosis

Internal Medicine Department, University of Calabar, Calabar 540242, Cross River State, Nigeria

Received 12 March 2014; Revised 7 May 2014; Accepted 7 May 2014; Published 7 July 2014

Academic Editor: Cristoforo Comi

Copyright © 2014 U. E. Williams et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. H. Noseworthy, C. Lucchinetti, M. Rodrigues, and B. G. Weinstenkern, “Multiple sclerosis,” The New England Journal of Medicine, vol. 343, no. 13, pp. 938–952, 2000. View at Publisher · View at Google Scholar
  2. A. Coles, “The Bare Essentials-Multiple sclerosis,” Practical Neurology, vol. 9, no. 2, pp. 118–126, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. C. C. Whitacre, “Sex differences in autoimmune disease,” Nature Immunology, vol. 2, no. 9, pp. 777–780, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Miller, F. Barkhof, X. Montalban, A. Thompson, and M. Filippi, “Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis,” Lancet Neurology, vol. 4, no. 5, pp. 281–288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. T. Okuda, E. M. Mowry, A. Beheshtian et al., “Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome,” Neurology, vol. 72, no. 9, pp. 800–805, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Pittock, R. L. McClelland, W. T. Mayr et al., “Clinical implications of benign multiple sclerosis: a 20-year population-based follow-up study,” Annals of Neurology, vol. 56, no. 2, pp. 303–306, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. R. Avasarala, A. H. Cross, and J. L. Trotter, “Oligoclonal band number as a marker for prognosis in multiple sclerosis,” Archives of Neurology, vol. 58, no. 12, pp. 2044–2045, 2001. View at Google Scholar · View at Scopus
  8. S. V. Ramagopalan, R. Dobson, U. C. Meier, and G. Giovannoni, “Multiple sclerosis: risk factors, prodromes, and potential causal pathways,” The Lancet Neurology, vol. 9, no. 7, pp. 727–739, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. G. Marrosu, R. Murru, M. R. Murru et al., “Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia,” Human Molecular Genetics, vol. 10, no. 25, pp. 2907–2916, 2001. View at Google Scholar · View at Scopus
  10. D. A. Hafler, A. Compston, S. Sawcer et al., “Risk alleles for multiple sclerosis identified by a genomewide study,” The New England Journal of Medicine, vol. 357, no. 9, pp. 851–862, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. F. Kurtzke, G. W. Beebe, and J. E. Norman Jr., “Epidemiology of multiple sclerosis in U.S. veterans: 1. Race, sex, and geographic distribution,” Neurology, vol. 29, no. 9, part 1, pp. 1228–1235, 1979. View at Google Scholar · View at Scopus
  12. A. Ascherio and K. L. Munger, “Environmental risk factors for multiple sclerosis. Part I: the role of infection,” Annals of Neurology, vol. 61, no. 4, pp. 288–299, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. M. A. Hernán, M. J. Olek, and A. Ascherio, “Cigarette smoking and incidence of multiple sclerosis,” The American Journal of Epidemiology, vol. 154, no. 1, pp. 69–74, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. S.-M. Orton, B. M. Herrera, I. M. Yee et al., “Sex ratio of multiple sclerosis in Canada: a longitudinal study,” Lancet Neurology, vol. 5, no. 11, pp. 932–936, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. I. A. F. van der Mei, A.-L. Ponsonby, T. Dwyer et al., “Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study,” British Medical Journal, vol. 327, no. 7410, pp. 316–320, 2003. View at Google Scholar · View at Scopus
  16. G. Dean and M. Elian, “Age at immigration to England of Asian and Caribbean immigrants and the risk of developing multiple sclerosis,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 63, no. 5, pp. 565–568, 1997. View at Publisher · View at Google Scholar
  17. R. Q. Hintzen and G. Giovannoni, “CSF analysis in suspected MS: do bands aid?” Neurology, vol. 70, no. 13, part 2, pp. 1059–1060, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Sospedra and R. Martin, “Molecular mimicry in multiple sclerosis,” Autoimmunity, vol. 39, no. 1, pp. 3–8, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Lukas, A. Minneboo, V. De Groot et al., “Early central atrophy rate predicts 5 year clinical outcome in multiple sclerosis,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 81, no. 12, pp. 1351–1356, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Patrikios, C. Stadelmann, A. Kutzelnigg et al., “Remyelination is extensive in a subset of multiple sclerosis patients,” Brain, vol. 129, pp. 3165–3172, 2006. View at Google Scholar
  21. J. W. Peterson and B. D. Trapp, “Neuropathobiology of multiple sclerosis,” Neurologic Clinics, vol. 23, no. 1, pp. 107–129, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. M. H. Barnett and J. W. Prineas, “Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion,” Annals of Neurology, vol. 55, no. 4, pp. 458–468, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Khoshnam and M. S. Freedman, “Disease-specific therapy of idiopathic inflammatory demyelinating disorders,” Expert Review of Neurotherapeutics, vol. 12, pp. 1113–1124, 2012. View at Publisher · View at Google Scholar
  24. I. Tsunoda and R. S. Fujinami, “Inside-out versus outside-in models for virus induced demyelination: axonal damage triggering demyelination,” Springer Seminars in Immunopathology, vol. 24, no. 2, pp. 105–125, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. E. M. Frohman, H. Zhang, P. D. Kramer et al., “MRI characteristics of the MLF in MS patients with chronic internuclear ophthalmoparesis,” Neurology, vol. 57, no. 5, pp. 762–768, 2001. View at Google Scholar · View at Scopus
  26. C. H. Polman, S. C. Reingold, B. Banwell et al., “Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria,” Annals of Neurology, vol. 69, no. 2, pp. 292–302, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Scolding, “The differential diagnosis of multiple sclerosis,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 71, supplement 2, pp. ii9–ii15, 2001. View at Google Scholar · View at Scopus
  28. L. M. Villar, J. Masjuan, M. C. Sádaba et al., “Early differential diagnosis of multiple sclerosis using a new oligoclonal band test,” Archives of Neurology, vol. 62, no. 4, pp. 574–577, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. Association of British Neurologists (ABN) revised, “Guidelines for Prescribing in multiple sclerosis,” 2009, http://www.theabn.org/abn/userfiles/file/ABN_MS_Guidelines_2009_Final.pdf.
  30. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group, “Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis,” The Lancet, vol. 352, no. 9153, pp. 1498–1504, 1998. View at Publisher · View at Google Scholar
  31. A. M. Palmer, “Pharmacotherapeutic options for the treatment of Multiple Sclerosis,” Clinical Medicine Insights: Therapeutics, vol. 4, pp. 145–168, 2012. View at Google Scholar
  32. D. D. Mikol, F. Barkhof, P. Chang et al., “Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial,” The Lancet Neurology, vol. 7, no. 10, pp. 903–914, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. C. H. Polman, P. W. O'Connor, E. Havrdova et al., “A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis,” The New England Journal of Medicine, vol. 354, no. 9, pp. 899–910, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. R. A. Rudick, W. H. Stuart, P. A. Calabresi et al., “Natalizumab plus interferon beta-1a for relapsing multiple sclerosis,” The New England Journal of Medicine, vol. 354, no. 9, pp. 911–923, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. National Institute for Health and Care Excellence (NICE), “Final appraisal determination-Fingolimod for the treatment of highly active relapsing-remitting multiple sclerosis,” TA254. Crown, Copyright, 2012.
  36. M. Matloubian, C. G. Lo, G. Cinamon et al., “Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1,” Nature, vol. 427, no. 6972, pp. 355–360, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. J. A. Cohen and J. Chun, “Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis,” Annals of Neurology, vol. 69, no. 5, pp. 759–777, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. W. O. Osburn and T. W. Kensler, “Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults,” Mutation Research, vol. 659, no. 1-2, pp. 31–39, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. E. J. Fox, “Mechanism of action of mitoxantrone,” Neurology, vol. 63, no. 12, pp. S15–S18, 2004. View at Google Scholar · View at Scopus
  40. V. Brinkmann, A. Billich, T. Baumruker et al., “Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis,” Nature Reviews Drug Discovery, vol. 9, no. 11, pp. 883–897, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Kappos, E.-W. Radue, P. O'Connor et al., “A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis,” The New England Journal of Medicine, vol. 362, no. 5, pp. 387–401, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. J. A. Cohen, F. Barkhof, G. Comi et al., “Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis,” The New England Journal of Medicine, vol. 362, no. 5, pp. 402–415, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. M. H. Hyland and J. A. Cohen, “Fingolimod,” Neurology: Clinical Practice, vol. 1, pp. 61–65, 2011. View at Publisher · View at Google Scholar
  44. R. J. Fox, D. H. Miller, J. T. Phillips et al., “Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis,” The New England Journal of Medicine, vol. 367, pp. 1087–1097, 2012. View at Publisher · View at Google Scholar
  45. P. O'Connor, J. S. Wolinsky, C. Confavreux et al., “Randomized trial of oral teriflunomide for relapsing multiple sclerosis,” The New England Journal of Medicine, vol. 365, no. 14, pp. 1293–1303, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. MS TRUST, “Treatments in Development,” 2013, http://www.mstrust.org.uk/research/drugsindevelopment/.
  47. B. Hemmer and H.-P. Hartung, “Toward the development of rational therapies in multiple sclerosis: what is on the horizon?” Annals of Neurology, vol. 62, no. 4, pp. 314–326, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. P. J. van der Most, A. M. Dolga, I. M. Nijholt, P. G. M. Luiten, and U. L. M. Eisel, “Statins: mechanism of neuroprotection,” Progress in Neurobiology, vol. 88, no. 1, pp. 64–75, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Floris, E. L. A. Blezer, G. Schreibelt et al., “Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study,” Brain, vol. 127, no. 3, pp. 616–627, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. A. S. Paintlia, M. K. Paintlia, A. K. Singh et al., “Regulation of gene expression associated with acute experimental autoimmune encephalomyelitis by Lovastatin,” Journal of Neuroscience Research, vol. 77, no. 1, pp. 63–81, 2004. View at Publisher · View at Google Scholar · View at Scopus
  51. G. Weitz-Schmidt, K. Welzenbach, V. Brinkmann et al., “Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site,” Nature Medicine, vol. 7, no. 6, pp. 687–692, 2001. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Chen, C. Zhang, H. Jiang et al., “Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice,” Journal of Cerebral Blood Flow and Metabolism, vol. 25, no. 2, pp. 281–290, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. D. Lu, C. Qu, A. Goussev et al., “Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury,” Journal of Neurotrauma, vol. 24, no. 7, pp. 1132–1146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. H. S. Keirstead, “Stem cells for the treatment of myelin loss,” Trends in Neurosciences, vol. 28, no. 12, pp. 677–683, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. E. Gerdoni, B. Gallo, S. Casazza et al., “Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis,” Annals of Neurology, vol. 61, no. 3, pp. 219–227, 2007. View at Publisher · View at Google Scholar · View at Scopus
  56. K. Noyes, A. Bajorska, A. Chappel et al., “Cost-effectiveness of disease-modifying therapy for multiple sclerosis: a population-based study,” Neurology, vol. 77, no. 4, pp. 355–363, 2011. View at Publisher · View at Google Scholar · View at Scopus